Palabras clave
Helicobacter pylori
Cáncer Gástrico
Cannabidiol
Concentración Inhibitoria Mínima
Cómo citar
Resumen
Introducción: El cáncer gástrico en Nariño, Colombia, es un problema de salud pública significativo debido a su alta incidencia y mortalidad. La erradicación de Helicobacter pylori (H. pylori) se considera una estrategia preventiva crucial, pero el fracaso de los tratamientos convencionales ha impulsado la búsqueda de alternativas. Los productos naturales, como el extracto de Cannabis sativa L. (C. sativa), están siendo evaluados por su potencial terapéutico. Objetivo: evaluar la actividad inhibitoria in vitro del extracto de C. sativa, rico en cannabidiol, frente al crecimiento de H. pylori aislado de pacientes con enfermedad gástrica en Nariño, Colombia. Metodología: Se aisló y purificó H. pylori a partir de biopsias gástricas de pacientes del Departamento de Nariño-Colombia. El extracto de C. sativa se obtuvo mediante extracción con dióxido de carbono (CO2) supercrítico. La actividad inhibitoria se evaluó utilizando el método de dilución en agar para determinar la concentración mínima inhibitoria (CMI). Resultados: La CMI del extracto de C. sativa contra H. pylori varió entre 35 y 55 µg/mL, indicando una eficacia significativa en la inhibición de la bacteria. Discusión: El extracto de C. sativa mostró un notable efecto inhibitorio sobre H. pylori, sugiriendo su potencial como alternativa terapéutica frente a tratamientos convencionales fallidos. Conclusion: El extracto de C. sativa rico en cannabidiol presenta una actividad inhibitoria efectiva in vitro contra H. pylori en pacientes de Nariño.
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Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Derechos de autor 2025 Diana Marcela Burbano-Vasquez, Alvaro Jairo Pazos-Moncayo, Andrés Mauricio Hurtado-Benavides, Yudy Banesa Legarda-Nastul, Oscar Arango-Bedoya