@article{Bueno Sánchez_Martínez Morales_Stashenko_2009, title={Actividad antimicobacteriana de terpenos}, volume={41}, url={https://revistas.uis.edu.co/index.php/revistasaluduis/article/view/686}, abstractNote={<p style="text-align: center;" align="center"><strong><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt;">RESUMEN </span></strong><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt;"></span></p><p style="text-align: justify;"><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt;">INTRODUCCIÓN:<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong>La tuberculosis (TB), causada por <em><span style="font-family: ";Verdana";,";sans-serif";;">Mycobacterium tuberculosis </span></em>es la mayor causa de mortalidad mundial por un único agente patógeno. Asimismo, un gran número de micobacterias no tuberculosas, especialmente <em><span style="font-family: ";Verdana";,";sans-serif";;">M. avium, M. intracellulare </span></em>y <em><span style="font-family: ";Verdana";,";sans-serif";;">M. chelonae</span></em>, causan infecciones oportunistas en pacientes con SIDA. Muchos terpenos poseen actividad biológica y se emplean en el tratamiento de diversas enfermedades, razón que los hace fuente de moléculas promisorias.<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong></span></p><p style="text-align: justify;"><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt;">OBJETIVO:<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong>El objetivo del presente estudio fue determinar la actividad antimicobacteriana de 16 terpenos contra <em><span style="font-family: ";Verdana";,";sans-serif";;">M. tuberculosis </span></em>H37Rv y un aislamiento clínico de <em><span style="font-family: ";Verdana";,";sans-serif";;">M. chelonae. </span></em><strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong></span></p><p style="text-align: justify;"><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt;">MATERIALES Y MÉTODOS: Se obtuvo la concentración mínima inhibitoria (CMI) de los mismos y se realizaron curvas de letalidad para establecer actividad bactericida, empleando una técnica de macrodilución en caldo estandarizada para este tipo de compuestos volátiles.<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong></span></p><p style="text-align: justify;"><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt;">RESULTADOS:<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong>Los terpenos con menor valor de CMI fueron timol y carvacrol, con concentraciones de 125-250 µg/mL, y actividad bactericida contra los dos microorganismos. Geraniol, mirceno, <em><span style="font-family: ";Verdana";,";sans-serif";;">p</span></em>-cimeno, alfa-pineno, presentaron valores de CMI entre 250 y 500 µg/mL.<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong></span></p><p style="text-align: justify;"><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt;">CONCLUSIONES:<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong>Algunos terpenos han presentado actividad importante contra microorganismos del género <em><span style="font-family: ";Verdana";,";sans-serif";;">Mycobacterium, </span></em>sin embargo los valores de CMI obtenidos no explican el efecto antimicrobiano presentado por el aceite completo, se requiere evaluar las interacciones de sinergismo y/o antagonismo entre los terpenos para determinar los componentes responsables de la acción farmacológica.<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong></span></p><p style="text-align: justify;"><strong><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt;">Palabras clave: </span></strong><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt;">Actividad antimicobacteriana, terpenos, tuberculosis<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong></span></p><p style="text-align: center;" align="center"><strong><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt; mso-ansi-language: EN-US;" lang="EN-US">ABSTRACT </span></strong><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt; mso-ansi-language: EN-US;" lang="EN-US"></span></p><p style="text-align: justify;"><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt; mso-ansi-language: EN-US;" lang="EN-US">INTRODUCTION:<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong>Tuberculosis (TB) caused by <em><span style="font-family: ";Verdana";,";sans-serif";;">Mycobacterium tuberculosis </span></em>is the major source of global mortality from a single pathogen. Moreover, a large number of nontuberculous mycobacteria, especially <em><span style="font-family: ";Verdana";,";sans-serif";;">M. avium, M. intracellulare </span></em>and <em><span style="font-family: ";Verdana";,";sans-serif";;">M. chelonae</span></em>, cause opportunistic infection in AIDS patients. Terpenes, possess a wide spectrum of biological activity and are used in the treatment of various diseases, reason that makes them a source of promising molecules.<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong></span></p><p style="text-align: justify;"><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt; mso-ansi-language: EN-US;" lang="EN-US">OBJECTIVE:<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong>To determine the antimycobacterial activity of 16 terpenes against <em><span style="font-family: ";Verdana";,";sans-serif";;">M. tuberculosis </span></em>H37Rv and a clinical isolate of <em><span style="font-family: ";Verdana";,";sans-serif";;">M. chelonae</span></em>.<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong></span></p><p style="text-align: justify;"><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt; mso-ansi-language: EN-US;" lang="EN-US">MATERIALS AND METHODS: Minimum Inhibitory Concentration (MIC) values of terpenes were obtained by macrodilution colorimetric method standardized for this kind of volatile compounds, time kill curves were determined to establish bactericidal activity using CLSIM26-A method.<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong></span></p><p style="text-align: justify;"><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt; mso-ansi-language: EN-US;" lang="EN-US">RESULTS:<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong>Terpenes with the lower MIC values were thymol and carvacrol at concentrations of 125-250 µg/mL, showing bactericidal activity against both microorganisms. Geraniol, myrcene, <em><span style="font-family: ";Verdana";,";sans-serif";;">p</span></em>-cymene, and alpha - pinene, showed MIC values ranging between 250-500 µg/mL.<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong></span></p><p style="text-align: justify;"><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt; mso-ansi-language: EN-US;" lang="EN-US">CONCLUSIÓN:<strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong>Some terpenes have presented signifcant activity against microorganisms of the <em><span style="font-family: ";Verdana";,";sans-serif";;">Mycobacterium </span></em>genus, but the MIC values obtained do not explain the antimicrobial effect showed by the complete oil, is necessary to assess the interactions of synergism and / or antagonism between the terpenes to determine the components responsible for Pharmacological. <strong><span style="font-family: ";Verdana";,";sans-serif";;"> </span></strong></span></p><p style="text-align: justify;"><strong><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt; mso-ansi-language: EN-US;" lang="EN-US">Keywords</span></strong><span style="font-family: ";Verdana";,";sans-serif";; color: black; font-size: 7pt; mso-ansi-language: EN-US;" lang="EN-US">: Antimycobacterial activity, terpenes, tuberculosis</span></p>}, number={3}, journal={Salud UIS}, author={Bueno Sánchez, Juan Gabriel and Martínez Morales, Jairo René and Stashenko, Elena}, year={2009}, month={dic.} }