Vol. 35 No. 2 (2022): Revista ION
Articles

Validation of a high-performance liquid chromatographic method for the simultaneous determination of diclofenac and ibuprofen in water resources

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  • Juliana Reyes Calle,
  • Alba Nelly Ardila Arias,
  • Yuleidy Balbin Olarte,
  • Sergio Andrés Bedoya Urrego,
  • Erasmo Arriola-Villaseñor,
  • Eliana Berrio Mesa
Juliana Reyes Calle
Politécnico Colombiano Jaime Isaza Cadavid
Alba Nelly Ardila Arias
Grupo de Investigación en Catálisis Ambiental y Energías Renovables (CAMER), Politécnico Colombiano Jaime Isaza Cadavid
Yuleidy Balbin Olarte
Grupo de Investigación en Catálisis Ambiental y Energías Renovables (CAMER), Politécnico Colombiano Jaime Isaza Cadavid
Sergio Andrés Bedoya Urrego
Grupo de Investigación en Catálisis Ambiental y Energías Renovables (CAMER), Politécnico Colombiano Jaime Isaza Cadavid
Erasmo Arriola-Villaseñor
Grupo de Investigación en Catálisis Ambiental y Energías Renovables (CAMER), Politécnico Colombiano Jaime Isaza Cadavid
Eliana Berrio Mesa
Grupo de Investigación en Catálisis Ambiental y Energías Renovables (CAMER), Politécnico Colombiano Jaime Isaza Cadavid
DOI: https://doi.org/10.18273/revion.v35n2-2022009

Published 2022-12-05

Keywords

  • Method validation,
  • High-performance liquid chromatography,
  • Diclofenac,
  • Ibuprofen,
  • Water resources

How to Cite

Reyes Calle, J., Ardila Arias, A. N. ., Balbin Olarte, Y. ., Bedoya Urrego, S. A. ., Arriola-Villaseñor, E. ., & Berrio Mesa, E. . (2022). Validation of a high-performance liquid chromatographic method for the simultaneous determination of diclofenac and ibuprofen in water resources. Revista ION, 35(2), 111–125. https://doi.org/10.18273/revion.v35n2-2022009

Copyright (c) 2022 Juliana Reyes Calle, Alba Nelly Ardila Arias, Yuleidy Balbin Olarte, Sergio Andrés Bedoya Urrego, Erasmo Arriola-Villaseñor, Eliana Berrio Mesa

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Diclofenac sodium and ibuprofen are highly consumed drugs, used for the relief of common ailments, their poor metabolization means that a large proportion of them become aquifer contaminants, this problem requires urgent attention. The monitoring of these contaminants, through the development and validation of analytical methodologies that allow their quantification in water resources, becomes a necessity to prevent and control them. In this study, a high-performance liquid chromatography method was developed for the simultaneous determination of diclofenac and ibuprofen in water. The validation of the method was carried out with the determination of linearity, limits of quantification and detection, accuracy and precision in terms of repeatability and intermediate precision. For the determination of the performance parameters, the percentage recovery, average, standard deviation, relative standard deviation, coefficient of variation and confidence interval were calculated. In addition, to determine the accuracy and precision, the factorial analysis of variance was applied with a confidence level of 95 % and a significance level of 0.05. The values obtained for all parameters complied with established acceptance criteria, confirming that the method developed is accurate and precise with high levels of reliability.

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