Artículos
Herramienta computacional para el análisis de mutaciones del VIH asociadas a susceptibilidad o resistencia a drogas
Publicado 2009-07-15
Palabras clave
- Bioinformática,
- resistencia,
- ADN,
- aminoácido,
- nucleótido
- proteasa,
- transcriptasa inversa ...Más
Cómo citar
Acero Barraza, S. M., Cervantes Acosta, G. J., & Zurek Varela, E. E. (2009). Herramienta computacional para el análisis de mutaciones del VIH asociadas a susceptibilidad o resistencia a drogas. Revista UIS Ingenierías, 8(1). Recuperado a partir de https://revistas.uis.edu.co/index.php/revistauisingenierias/article/view/239
Resumen
Este artículo presenta el desarrollo e implementación de un sistema que sirva como herramienta para el estudio y exploración del VIH a partir del análisis computacional de sus mutaciones, teniendo en cuenta la información genética del mismo. El análisis se realiza empleando la información contenida en la secuencia genética del VIH y comparándola con secuencias de referencia. Se presenta una descripción de algoritmos para alineamiento, identifcación de mutaciones y análisis de resistencia aplicados a la secuencia genética del virus.
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Referencias
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L. A. N. Laboratory, “ADRA: Antiviral Drug Resistance Analysis,” Los Alamos National Laboratory, 2007.
S. J. Little and S. Holte, “Antiretroviral-Drug Resistance among Patients Recently Infected with HIV,” The New Englad Journal of Medicine, vol. 347, pp. 385-394, Agosto 8 2002 2002.
E. K. Wagner and M. J. Hewlett., Basic Virology, 2, Illustrated ed.: Blackwell Publishing, 2004.
Mount and W. David, “Bioinformatics: Sequence and Genome Analysis,” New York: Cold Spring Harbor Laboratory Press., 2001.
M. H. Schierupa and J. Hein, “Consequences of Recombination on Traditional Phylogenetic Analysis,” Genetics, vol. 156, pp. 879-891, Octubre 2000 2000.
M. Schena, “DNA Microarrays: A practical Approach,” O. U. Press, Ed., 1999, p. 232.
G. C. Menéndez-Arias, “DR_SEQAN: a PC/ Windows-based software to evaluate drug,” BMC Infectious Diseases, vol. 6, 2006.
H. Tao, “Drug Resistance Mutations Superimposed on the Structures of HIV-1 Proteaseand Reverse Transcriptase,” in HIV Molecular Immunology Database New Mexico: Theoretical Biology and Biophysics Group, 1997.
D. L. Hartl, Essential Genetics: A Genomics Perspective, 3 ed.: Jones and Bartlett Publishers, 1995, 1995.
B. N. Fields, D. M. Knipe, P. M. Howley, and D. E. Griffn, Fields’ virology, 5 ed.: Lippincott Williams & Wilkins, 2006.
S. B. Needleman and C. D. Wunsch, “A general method Applicable to the search for similarities in the aminoacid sequence or twon proteins,” J. Mol. Biol., vol. 48, pp. 443-453, 1970.
N. Beerenwinkel, T. Lengauer, J. Selbig, B. Schmidt, H. Walte, K. Korn, R. Kaiser, and D. Hoffmann., “Geno2pheno: interpreting genotypic HIV drug resistance tests,” Intelligent Systems, IEEE, vol. 16, pp. 35-41, nov - dic 2001 2001.
C. Pasquier, N. Millot, R. Njouom, K. Sandres, M. Cazabat, J. Puel, and J. Izopet, “HIV-1 subtyping using phylogenetic analysis of pol gene sequences,” Journal of vyrological Methods, vol. 92, pp. 45-54,
Abril 30 2001 2001.
M. S. Hirsch, “HIV Drug Resistance - A Chink in the Armor,” The New Englad Journal of Medicine, vol. 347, pp. 438-439, Agosto 8 2002 2002.
C. Yabar, P. Chavez, Z. Varas, and R. Rodriguez, “Identifcación molecular de mutaciones puntuales relacionadas con resistencia a drogas en VIH-1 de pacientes peruanos,” Revista Peruana de Medicina experimental y Salud Publica, vol. 23, pp. 149-157, Julio - Septiembre 2006 2006.
N. J. Dimmock, A. Easton, and K. Leppard, Introduction to Modern Virology, 5, Illustrated ed.: Blackwell Publishing, 2001.
R. G. Cotton, E. Edkins, and S. Forrest, “Mutation Detection: A practical Approach,” Oxford University Press, 1999, p. 264.
S. Clark, C. Calef, and J. Mellors, “Mutations in Retroviral Genes Associated with Drug Resistance “ in HIV Sequence Compendium 2006/200, F. B. Thomas Leitner T, Hahn B, Marx P, McCutchan F, Mellors J, Wolinsky S, Korber B., Ed.: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM. LA-UR 07- 4826, 2007, pp. 58-158.
W. M. Fitch and T. F. Smith, “Optimal Sequence Alignments,” Procedings of the National Academy of Sciences of the United States of America, vol. 80, pp. 1382-1386, 1983.
M. M. Miyamoto and J. Cracraft, “Phylogenetic Analysis of DNA Sequences,” New York: Oxford University Press, Incorporated, 1991, p. 369.
D. Costagliola, L. Assoumou, and L. MorandJoubert, “Prevalence of HIV-1 drug resistance in treated patients - A French nationwide study,” JAIDSJournal Of Acquired Immune Defciency Syndromes, vol. 46, pp. 12-18, septiembre 1 2007 2007.
J. M. Coffn, S. H. Hughes, and H. E. Varmus, Retroviruses, illustrated ed.: CSHL Press, 1997.
Y. Xing, “Sequence Alignment Algorithm,” in School of electronics Engineering and Computer Science Beijing: Peking University, 2005.
A. Abecasis, A. Vandamme, and P. Lemey, “Sequence Alignment in HIV Computational Analysis “ in HIV Sequence Compendium 2006/2007: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM. LA-UR 07-4826, 2007.
S.Yerly, L. Kaiser, E. Race, J. Bru, F. Clavel, and LPerrin, “Transmision of antirretroviral drug-resistant HIV-1 variants,” Lancet, vol. 354, p. 729, 1999.
V. A. Johnson and F. Brun-Vézinet, “Update of the drug Resistance Mutations in HIV-1,” Topics in HIV Medicine, vol. 16, pp. 62-68, 2008.
W. E. Highsmith, Q. Jin, A. J. Nataraj, J. M. O’Connor, V. D. Burland, W. R. Baubonis, F. P. Curtis, N. Kusukawa, and M. M. Garner, “Use of a DNA toolbox for the characterization of mutation scanning methods. I: Construction of the toolbox and evaluation of heteroduplex analysis,” Electropheresis, vol. 20, pp. 1186-1194, Mayo 26 1999 1999.
V. G. S. Merino, “Variacion de los genes accesorios y su implicacion en la biología del vih-1,” in Departamento de microbiología II. vol. Doctor Madrid: Universidad Complutense de Madrid, 2001, p. 700.