Revista Integración, temas de matemáticas.
Vol. 26 No. 1 (2008): Revista Integración, temas de matemáticas
Research and Innovation Articles

A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization

Carlos Cabal-Mirabal
Bio
Iván Ruiz-Chaveco
Bio

Published 2008-02-29

Keywords

  • Polymerization,
  • Hemoglobin S,
  • Sickle Cell, Modeling

How to Cite

Cabal-Mirabal, C., & Ruiz-Chaveco, I. (2008). A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization. Revista Integración, Temas De matemáticas, 26(1), 13–22. Retrieved from https://revistas.uis.edu.co/index.php/revistaintegracion/article/view/53

Abstract

The molecular aggregate formation mechanisms play a major role in the interpretation of the pathophysiology of Sickle Cell disease and in the selection of the therapeutic strategies to follow. 

A mechanism and a mathematical model are proposed. The model postu-lates the existence of defective microtubules formed by deoxy hemoglobin S and oxy hemoglobin S, and explains the dependence of polymerization on hemoglobin concentration, temperature, and partial oxygen pressure. The analysis focuses on the polymerization of hemoglobin S in the absence of crystallization. The action of other kinds of hemoglobin in the molecular aggregate formation process can be explained. 

 

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