Simulation and conceptual design of a dl-methionine production process by the chemical synthesis route
Published 2024-05-08
Keywords
- dl-methionine,
- process simulation,
- profitability indicators,
- SuperPro Designer,
- techno-economic evaluation
How to Cite
Copyright (c) 2024 Amaury Pérez Sánchez, Arlette González Abad, Amanda Acosta Solares, Elizabeth Ranero González, Eddy Javier Pérez Sánchez
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
Methionine is one of the two sulfur-containing amino acids demanded in the diet of humans, other mammals and avian species, while most of the produced methionine is consumed as an animal feed additive, especially in livestock production and the poultry market. In this paper, the techno-economic assessment and conceptual design of an industrial scale, feed grade dl-methionine production process was carried out using SuperPro Designer simulator. The plant was designed to produce 109 tons of dl-methionine per year through the chemical synthesis route. The total capital investment and annual operating cost of the proposed plant were USD $ 8.282 million and USD $ 1.323 million, respectively, while the net present value, the internal rate of return and payback time of the project were USD $ 4.436 million, 20.33 % and 4.74 years, respectively. The findings indicated that the proposed production process is feasible and profitable for a dl-methionine selling price of USD $ 35/kg. The innovative simulation model obtained in this work could be used for further optimization studies, as well as to increase the productivity and profitability of the proposed plant.
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References
- Zhou H, Wu W, Niu K, Xu Y, Liu Z, Zheng Y. Enhanced L-methionine production by genetically engineered Escherichia coli through fermentation optimization. 3 Biotech. 2019;9(96):1-11. https://doi.org/10.1007/s13205-019-1609-8
- Willke T. Methionine production-a critical review. Appl Microbiol Biotechnol. 2014;98:9893-9914. https://doi.org/10.1007/s00253-014-6156-y
- Reports and Data. Materials and Chemicals - Methionine Market April 2023 (Online). Reports and Data. Available from: https://www.reportsanddata.com/report-detail/methioninemarket. Accessed on October 8th, 2023.
- Data Bridge Market Research. Global Methionine Market – Industry Trends and Forecast to 2030 (Online). Data Bridge Market Research. Available from: https://www.databridgemarketresearch.com/reports/global-methionine-market. Accessed on October 8th, 2023.
- Xiong N, Yu R, Chen T, Xue Y-P, Liu Z-Q, Zheng Y-G. Separation and purification of L-methionine from E. coli fermentation broth by macroporous resin chromatography. Journal of Chromatography B. 2019;1110-1111:108-15.
- https://doi.org/10.1016/j.jchromb.2019.02.016
- Mohany NAM, Totti A, Naylor KR, Janovjak H. Microbial methionine transporters and biotechnological applications. Applied Microbiology and Biotechnology.2021;105:3919-29. https://doi.org/10.1007/s00253-021-11307-w
- Mari JU, Aliyu A, Nasiru S, Muhammad AB, Ibrahim AA, Magaji H, et al. Methionine Production and Optimization Using Bacillus cereus Isolated From Soil. Scholars International Journal of Biochemistry. 2022;5(7):95-102. https://doi.org/10.36348/sijb.2022.v05i07.001
- Krömer JO, Wittmann C, Schröder H, Heinzle E. Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum. Metabolic Engineering. 2006;8:353–69. https://doi.org/10.1016/j.ymben.2006.02.001
- Anakwenze VN, Ezemba CC, Ekwealor IA. Optimization of Fermentation Conditions of Bacillus thuringiensis EC1 for Enhanced Methionine Production. Advances in Microbiology. 2014;4:344-52.
- Ranjan AP, Nayak R, Gomes J. A model for L-methionine production describing oxygen–productivity relationship. J Chem Technol Biotechnol. 2009;84:662-74. https://doi.org/10.1002/jctb.2097
- Li Z, Liu Q, Sun J, Sun J, Li M, Zhang Y, et al. Multivariate modular metabolic engineering for enhanced L-methionine biosynthesis in Escherichia coli. Biotechnology for Biofuels and Bioproducts. 2023;16(101):1-15.
- Wang H, Li Y, Che Y, Yang D, Wang Q, Yang H, et al. Production of L-Methionine from 3-Methylthiopropionaldehyde and O-Acetylhomoserine by Catalysis of the Yeast O-Acetylhomoserine Sulfhydrylase. Journal of Agricultural and Food Chemistry. 2021;69:7932-7. https://doi.org/10.1021/acs.jafc.1c02419
- Mai NL, Koo Y-M. Enhanced enzyme-catalyzed synthesis of L-methionine with ionic liquid additives. Process Biochemistry. 2019;77:31-6. https://doi.org/10.1016/j.procbio.2018.11.020
- Gomes J, Kumar D. Production of l-methionine by submerged fermentation: A review. Enzyme and Microbial Technology. 2005;37:3-18. https://doi.org/10.1016/j.enzmictec.2005.02.008
- Kumar D, Gomes J. Methionine production by fermentation. Biotechnology Advances. 2005;23:41-61. https://doi.org/10.1016/j.biotechadv.2004.08.005
- Reershemius HK. Production of L-methionine with Corynebacterium glutamicum (PhD thesis). Lower Saxony, Germany: Technical University of Braunschweig; 2008.
- Intratec Solutions LLC. D,L-Methionine Production via the Carbonate Process. Chemical Engineering. 2014;121(11):38.
- Guedes PHPS, Luz RF, Cavalcante RM, Young AF. Process simulation for technical and economic evaluation of acrolein and glycerol carbonate production from glycerol. Biomass and Bioenergy. 2023;168:106659. https://doi.org/10.1016/j.biombioe.2022.106659
- ChemAnalyst. Ammonium carbonate: Price Trend and Forecast (Online). ChemAnalyst. Available from: https://www.chemanalyst.com/Pricing-data/ammonium-carbonate-1290. Accessed on October 3rd, 2023.
- IndexBox. Hydrogen Cyanide (Online). IndexBox. Available from: https://www.indexbox.io/search/price-for-hydrogencyanide-hydrocyanic-acid-the-united-states/. Accessed on October 4th, 2023.
- ChemAnalyst. Methanol Price Trend and Forecast (Online). ChemAnalyst. Available from: https://www.chemanalyst.com/Pricingdata/methanol-1. Accessed on October 3rd, 2023.
- ChemicalBook. Methyl mercaptan (Online). ChemicalBook. Available from: https://www.chemicalbook.com/ChemicalProductProperty_EN_CB7106671.htm. Accessed on October 5th, 2023.
- ChemAnalyst. Caustic Soda Price Trend and Forecast (Online). ChemAnalyst. Available from: https://www.chemanalyst.com/Pricingdata/caustic-soda-3. Accessed on October 3rd, 2023.
- ChemAnalyst. Hydrochloric acid Price Trend and Forecast (Online). ChemAnalyst. Available from: https://www.chemanalyst.com/Pricing-data/hydrochloric-acid-61. Accessed on October 3rd, 2023.
- Harrison RG, Todd PW, Rudge SR, Petrides DP. Bioseparations science and engineering. 2nd ed. New York, USA: Oxford University Press; 2015.
- Silla H. Chemical Process Engineering. New York, USA: Marcel Dekker, Inc; 2003.
- Peters MS, Timmerhaus KD, West RE. Plant Design and Economics for Chemical Engineers. 5th ed. New York, USA: McGraw-Hill; 2003.
- Brown T. Engineering Economics and Economic Design for Process Engineers. Boca Raton, USA: CRC Press; 2006.
- MatChe. Chemical Equipment Cost 2014 (Online). MatChe. Available from: www.matche.com. Accessed on October 10, 2023.
- Sinnott R, Towler G. Chemical Engineering Design. 6th ed. Oxford, United Kingdom: Butterworth-Heinemann; 2020.
- Jenkins S. Economic Indicators. Chemical Engineering. 2023;130(10):48.
- Couper JR, Penney WR, Fair JR, Walas SM. Chemical Process Equipment - Selection and Design. 3rd ed. Oxford, UK: Butterworth-Heinemann; 2012.
- Green DW, Southard MZ. Perry’s Chemical Engineers’ Handbook. 9th ed. New York, USA: McGraw-Hill Education; 2019.
- Gebremariam SN, Marchetti JM. Process simulation and techno-economic performance evaluation of alternative technologies for biodiesel production from low value non-edible oil. Biomass and Bioenergy. 2021;149:106102. https://doi.org/10.1016/j.biombioe.2021.106102
- Petrides D. Bioprocess Design and Economics. New Jersey, USA: Intelligen, Inc; 2015.
- FasterCapital. Los desafíos de la sostenibilidad de costos en diferentes industrias y regiones (Online). Available from: https://fastercapital.com/es/tema/los-desaf%C3%ADos-de-la-sostenibilidad-de-costos-en-diferentes-industrias-y-regiones.html. Accessed on April 30th, 2024.