v. 37 n. 1 (2024): Revista ION
Artigos

Simulação e projeto conceitual de processo de produção de dl-metionina através da rota de síntese química

PDF (English)
  • Amaury Pérez Sánchez,
  • Arlette González Abad,
  • Amanda Acosta Solares,
  • Elizabeth Ranero González,
  • Eddy Javier Pérez Sánchez
Amaury Pérez Sánchez
Universidad de Camagüey
Arlette González Abad
Universidad de Camagüey
Amanda Acosta Solares
Universidad Central de Las Villas
Elizabeth Ranero González
Universidad de Camagüey
Eddy Javier Pérez Sánchez
Empresa Servicios Automotores S.A
DOI: https://doi.org/10.18273/revion.v37n1-2024005

Publicado 2024-05-08

Palavras-chave

  • Dl-metionina,
  • Simulação de processos,
  • Indicadores de rentabilidade ,
  • SuperPro Designer,
  • Avaliação técnico-econômica

Como Citar

Pérez Sánchez, A., González Abad, . A. de la C. ., Acosta Solares, A. ., Ranero González, E. ., & Pérez Sánchez, E. J. . (2024). Simulação e projeto conceitual de processo de produção de dl-metionina através da rota de síntese química. REVISTA ION, 37(1), 65–81. https://doi.org/10.18273/revion.v37n1-2024005

Copyright (c) 2024 Amaury Pérez Sánchez, Arlette González Abad, Amanda Acosta Solares, Elizabeth Ranero González, Eddy Javier Pérez Sánchez

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

Resumo

A metionina é um dos dois aminoácidos contendo enxofre necessário na dieta de humanos, outros
mamíferos e espécies aviárias, enquanto a maior parte da metionina produzida é usada como aditivos na alimentação animal, especialmente na produção pecuária e no mercado avícola. Neste artigo foi realizada a avaliação técnico-econômica e o projeto conceitual de um processo de produção de dlmetionina de qualidade alimentar em escala industrial utilizando o simulador SuperPro Designer. A planta foi projetada para produzir 109 t de dl-metionina por ano por meio de síntese química. O investimento total de capital e o custo operacional anual da planta proposta foram de US$ 8,282 milhões e US$ 1,323 milhões, respectivamente, enquanto o valor presente líquido, a taxa interna de retorno e o período de retorno do projeto da planta proposta foram de US$ 4,436 milhões, 20,33% e 4,74 anos, respectivamente. As descobertas indicaram que o processo de produção proposto é viável e rentável para um preço de venda de dl-metionina de US$ 35/kg. O inovador modelo de simulação obtido neste trabalho poderá ser utilizado para posteriores estudos de optimização, bem como para aumentar a produtividade e lucratividade da planta proposta.

PDF (English)

Downloads

Não há dados estatísticos.

Referências

  1. Zhou H, Wu W, Niu K, Xu Y, Liu Z, Zheng Y. Enhanced L-methionine production by genetically engineered Escherichia coli through fermentation optimization. 3 Biotech. 2019;9(96):1-11. https://doi.org/10.1007/s13205-019-1609-8
  2. Willke T. Methionine production-a critical review. Appl Microbiol Biotechnol. 2014;98:9893-9914. https://doi.org/10.1007/s00253-014-6156-y
  3. Reports and Data. Materials and Chemicals - Methionine Market April 2023 (Online). Reports and Data. Available from: https://www.reportsanddata.com/report-detail/methioninemarket. Accessed on October 8th, 2023.
  4. Data Bridge Market Research. Global Methionine Market – Industry Trends and Forecast to 2030 (Online). Data Bridge Market Research. Available from: https://www.databridgemarketresearch.com/reports/global-methionine-market. Accessed on October 8th, 2023.
  5. Xiong N, Yu R, Chen T, Xue Y-P, Liu Z-Q, Zheng Y-G. Separation and purification of L-methionine from E. coli fermentation broth by macroporous resin chromatography. Journal of Chromatography B. 2019;1110-1111:108-15.
  6. https://doi.org/10.1016/j.jchromb.2019.02.016
  7. Mohany NAM, Totti A, Naylor KR, Janovjak H. Microbial methionine transporters and biotechnological applications. Applied Microbiology and Biotechnology.2021;105:3919-29. https://doi.org/10.1007/s00253-021-11307-w
  8. Mari JU, Aliyu A, Nasiru S, Muhammad AB, Ibrahim AA, Magaji H, et al. Methionine Production and Optimization Using Bacillus cereus Isolated From Soil. Scholars International Journal of Biochemistry. 2022;5(7):95-102. https://doi.org/10.36348/sijb.2022.v05i07.001
  9. Krömer JO, Wittmann C, Schröder H, Heinzle E. Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum. Metabolic Engineering. 2006;8:353–69. https://doi.org/10.1016/j.ymben.2006.02.001
  10. Anakwenze VN, Ezemba CC, Ekwealor IA. Optimization of Fermentation Conditions of Bacillus thuringiensis EC1 for Enhanced Methionine Production. Advances in Microbiology. 2014;4:344-52.
  11. Ranjan AP, Nayak R, Gomes J. A model for L-methionine production describing oxygen–productivity relationship. J Chem Technol Biotechnol. 2009;84:662-74. https://doi.org/10.1002/jctb.2097
  12. Li Z, Liu Q, Sun J, Sun J, Li M, Zhang Y, et al. Multivariate modular metabolic engineering for enhanced L-methionine biosynthesis in Escherichia coli. Biotechnology for Biofuels and Bioproducts. 2023;16(101):1-15.
  13. Wang H, Li Y, Che Y, Yang D, Wang Q, Yang H, et al. Production of L-Methionine from 3-Methylthiopropionaldehyde and O-Acetylhomoserine by Catalysis of the Yeast O-Acetylhomoserine Sulfhydrylase. Journal of Agricultural and Food Chemistry. 2021;69:7932-7. https://doi.org/10.1021/acs.jafc.1c02419
  14. Mai NL, Koo Y-M. Enhanced enzyme-catalyzed synthesis of L-methionine with ionic liquid additives. Process Biochemistry. 2019;77:31-6. https://doi.org/10.1016/j.procbio.2018.11.020
  15. Gomes J, Kumar D. Production of l-methionine by submerged fermentation: A review. Enzyme and Microbial Technology. 2005;37:3-18. https://doi.org/10.1016/j.enzmictec.2005.02.008
  16. Kumar D, Gomes J. Methionine production by fermentation. Biotechnology Advances. 2005;23:41-61. https://doi.org/10.1016/j.biotechadv.2004.08.005
  17. Reershemius HK. Production of L-methionine with Corynebacterium glutamicum (PhD thesis). Lower Saxony, Germany: Technical University of Braunschweig; 2008.
  18. Intratec Solutions LLC. D,L-Methionine Production via the Carbonate Process. Chemical Engineering. 2014;121(11):38.
  19. Guedes PHPS, Luz RF, Cavalcante RM, Young AF. Process simulation for technical and economic evaluation of acrolein and glycerol carbonate production from glycerol. Biomass and Bioenergy. 2023;168:106659. https://doi.org/10.1016/j.biombioe.2022.106659
  20. ChemAnalyst. Ammonium carbonate: Price Trend and Forecast (Online). ChemAnalyst. Available from: https://www.chemanalyst.com/Pricing-data/ammonium-carbonate-1290. Accessed on October 3rd, 2023.
  21. IndexBox. Hydrogen Cyanide (Online). IndexBox. Available from: https://www.indexbox.io/search/price-for-hydrogencyanide-hydrocyanic-acid-the-united-states/. Accessed on October 4th, 2023.
  22. ChemAnalyst. Methanol Price Trend and Forecast (Online). ChemAnalyst. Available from: https://www.chemanalyst.com/Pricingdata/methanol-1. Accessed on October 3rd, 2023.
  23. ChemicalBook. Methyl mercaptan (Online). ChemicalBook. Available from: https://www.chemicalbook.com/ChemicalProductProperty_EN_CB7106671.htm. Accessed on October 5th, 2023.
  24. ChemAnalyst. Caustic Soda Price Trend and Forecast (Online). ChemAnalyst. Available from: https://www.chemanalyst.com/Pricingdata/caustic-soda-3. Accessed on October 3rd, 2023.
  25. ChemAnalyst. Hydrochloric acid Price Trend and Forecast (Online). ChemAnalyst. Available from: https://www.chemanalyst.com/Pricing-data/hydrochloric-acid-61. Accessed on October 3rd, 2023.
  26. Harrison RG, Todd PW, Rudge SR, Petrides DP. Bioseparations science and engineering. 2nd ed. New York, USA: Oxford University Press; 2015.
  27. Silla H. Chemical Process Engineering. New York, USA: Marcel Dekker, Inc; 2003.
  28. Peters MS, Timmerhaus KD, West RE. Plant Design and Economics for Chemical Engineers. 5th ed. New York, USA: McGraw-Hill; 2003.
  29. Brown T. Engineering Economics and Economic Design for Process Engineers. Boca Raton, USA: CRC Press; 2006.
  30. MatChe. Chemical Equipment Cost 2014 (Online). MatChe. Available from: www.matche.com. Accessed on October 10, 2023.
  31. Sinnott R, Towler G. Chemical Engineering Design. 6th ed. Oxford, United Kingdom: Butterworth-Heinemann; 2020.
  32. Jenkins S. Economic Indicators. Chemical Engineering. 2023;130(10):48.
  33. Couper JR, Penney WR, Fair JR, Walas SM. Chemical Process Equipment - Selection and Design. 3rd ed. Oxford, UK: Butterworth-Heinemann; 2012.
  34. Green DW, Southard MZ. Perry’s Chemical Engineers’ Handbook. 9th ed. New York, USA: McGraw-Hill Education; 2019.
  35. Gebremariam SN, Marchetti JM. Process simulation and techno-economic performance evaluation of alternative technologies for biodiesel production from low value non-edible oil. Biomass and Bioenergy. 2021;149:106102. https://doi.org/10.1016/j.biombioe.2021.106102
  36. Petrides D. Bioprocess Design and Economics. New Jersey, USA: Intelligen, Inc; 2015.
  37. FasterCapital. Los desafíos de la sostenibilidad de costos en diferentes industrias y regiones (Online). Available from: https://fastercapital.com/es/tema/los-desaf%C3%ADos-de-la-sostenibilidad-de-costos-en-diferentes-industrias-y-regiones.html. Accessed on April 30th, 2024.

Artigos mais lidos pelo mesmo(s) autor(es)