Avances en la búsqueda de la vacuna contra Helicobacter pylori

  • Jose Augusto Urrego Universidad Nacional de Colombia
  • William Otero Universidad Nacional de Colombia
  • Alba Trespalacios Pontificia Universidad Javeriana

Resumen

Helicobacter pylori es una bacteria que infecta la mucosa gástrica de alrededor de la mitad de la población mundial y está involucrada en la patogénesis de un gran número de enfermedades gástricas y extragástricas en el huésped. Varios antígenos, adyuvantes y rutas de inmunización han sido evaluados buscando una vacuna que ayude a prevenir o erradicar la infección, consiguiéndose diferentes grados de éxito, si bien la inmunidad esterilizante solo se ha conseguido en algunos modelos animales. Varios mecanismos se han propuesto para explicar los resultados obtenidos con las vacunas potenciales evaluadas y para explicar cómo esta bacteria elude la respuesta inmune inducida por ella misma o por intentos de inmunización. El panorama hasta el momento, si bien no parece sencillo, no deja de ser esperanzador por los favorables resultados que vendrían tras la obtención de una vacuna eficaz y por algunos estudios que motivan a la posibilidad de su consecución. MÉD.UIS. 2017;30(3):111-20.

Palabras clave: Helicobacter pylori, Vacunación, Antígenos, Inmunización, Neoplasias Gástricas, Ureasa

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Biografía del autor

Jose Augusto Urrego, Universidad Nacional de Colombia

Médico cirujano. Residente I año Medicina Interna. Facultad de Medicina. Universidad Nacional de Colombia. Bogotá D.C. Colombia.

William Otero, Universidad Nacional de Colombia

Médico gastroenterólogo. Clínica Los Fundadores. Profesor Titular de Medicina. Unidad de Gastroenterología. Universidad Nacional de Colombia. Bogotá D.C. Colombia.

Alba Trespalacios, Pontificia Universidad Javeriana

Bacterióloga. Magister en Microbiología. Doctora en Ciencias Biológicas. Profesora Titular de Bacteriología. Facultad de Ciencias. Pontificia Universidad Javeriana. Bogotá D.C. Colombia.

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Publicado
2017-11-21
Cómo citar
URREGO, Jose Augusto; OTERO, William; TRESPALACIOS, Alba. Avances en la búsqueda de la vacuna contra Helicobacter pylori. REVISTA MÉDICAS UIS, [S.l.], v. 30, n. 3, p. 111-20, nov. 2017. ISSN 1794-5240. Disponible en: <http://revistas.uis.edu.co/index.php/revistamedicasuis/article/view/7303>. Fecha de acceso: 17 dic. 2017 doi: https://doi.org/10.18273/revmed.v30n3-2017012.
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