Células T modificadas con receptores quiméricos de antígeno: ingeniería genética y aplicaciones clínicas en cáncer pediátrico. Revisión de la literatura
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Palabras clave

Receptores quiméricos de antígenos
Linfocitos T
Ingeniería genética
Inmunoterapia adoptiva
Neoplasias
Protocolos antineoplásicos
Pediatría

Cómo citar

Gutiérrez-Castañeda, L. D., Camacho-Cruz, J., Torres Juez, C. P., Freire Durán, A. S., Quintero Alba, B. A., Olarte Suárez, L. D., Castro Díaz, Óscar E., Cruz López, Y., León Gómez, K. T., Pacheco Rojas, L. C., Parrado Herrera, P. H., Villamizar Sánchez, L. F., & Carvajal Veloza, J. (2023). Células T modificadas con receptores quiméricos de antígeno: ingeniería genética y aplicaciones clínicas en cáncer pediátrico. Revisión de la literatura. Médicas UIS, 36(3), 65–81. https://doi.org/10.18273/revmed.v36n3-2023006

Resumen

El cáncer en niños y adolescentes comprende un grupo heterogéneo de neoplasias. Dentro de estas, la leucemia es la más frecuente. Actualmente, la inmunoterapia con anticuerpos monoclonales y la terapia celular adoptiva basada en la modificación por medio de ingeniería genética de las células T representa una gran oportunidad para los pacientes que no responden a las terapias convencionales. Una de las inmunoterapias aprobadas por agencias reguladoras europeas y estadounidenses que ha mostrado seguridad y eficacia son las células T modificadas con receptores quiméricos de antígeno que reconocen el antígeno CD19 en pacientes con leucemia linfoblástica aguda. Asimismo, la terapia ha demostrado ser exitosa en pacientes pediátricos con leucemia linfoblástica aguda B refractaria o en segunda recaída. Esta revisión describe la ingeniería genética para la generación de las células T modificadas con receptores quiméricos de antígeno, sus aplicaciones clínicas y la efectividad de los ensayos clínicos actuales en pacientes pediátricos.

https://doi.org/10.18273/revmed.v36n3-2023006
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