Patrones de prescripción de vitaminas y suplementos nutricionales en un grupo de pacientes de Colombia
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Keywords

Vitamins
Dietary supplements
Drug prescriptions
Prescription Drug Misuse
Pharmacoepidemiology
Colombia.

How to Cite

Machado-Duque, M. E., Ayala-Torres, J. D., & Machado-Alba, J. E. (2020). Patrones de prescripción de vitaminas y suplementos nutricionales en un grupo de pacientes de Colombia. Médicas UIS, 33(2), 41–48. https://doi.org/10.18273/revmed.v33n2-2020005

Abstract

Introduction: Vitamins and micronutrients are essential organic substances in the metabolic processes of living things, and supplementation is only recommended in conditions of nutritional deficits. Objective: To determine the prescription patterns of vitamins and supplements in a group of patients enrolled in the Colombian Health System in 2016. Methodology: This was a cross-sectional study based on a population database. Vitamin-prescribed patients of both sexes and all ages were selected for 3 consecutive months. A database was designed using the dispensing records. SPSS 23.0 was used for the univariate, bivariate and multivariate analyses. A p-value <0.05 was considered statistically significant. Results: In total, 9998 patients receiving vitamin supplementation were identified. A female predominance was observed (n=8341, 83.4%). The mean age was 57.7±18.7 years. The most commonly formulated vitamins and micronutrients were vitamin D (58.0%), calcium (55.0%) and folic acid (25.0%). Overall, 60.8% of patients were prescribed more than one vitamin. The most frequent multiple-nutrient association was between calcium and vitamin D (n=5505); 77.3% received concurrent treatment with other medications
to manage comorbidities. The probability of comedication in the multivariate analysis was higher for folic acid (OR:3.10, 95%CI 2.69-3.59), thiamine (OR:2.75, 95%CI:2.15-3.5) and calcium + vitamin D (OR:1.61, 95%CI: 1.42-1.82) and for those individuals older than 65 years (OR:1.24, 95%CI:1.02-1.51). Conclusions: Vitamins are widely used in the Colombian population. The results of this study elucidate the patterns of use of these supplements and offer proposed strategies to the future and to evaluate and minimize prescriptions that are potentially inappropriate or of little therapeutic value. MÉD.UIS. 2020;33(2):41-8.

https://doi.org/10.18273/revmed.v33n2-2020005
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References

Brito A, Hertrampf E, Olivares M, Gaitan D, Sanchez H, Allen LH, et al. Folate, vitamin B12 and human health. Rev Med Chil. 2012;140(11):1464-75. DOI:10.4067/S0034-98872012001100014

Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, et al. The nonskeletal effects of vitamin D: an Endocrine
Society scientific statement. Endocr Rev. 2012;33(3):456-92. DOI:10.1210/er.2012-1000

Ramírez-Vélez R, Correa-Bautista JE, Martínez-Torres J, Meneses- Echávez JF, Lobelo F. Vitamin B12 concentrations in pregnant Colombian women: analysis of nationwide data 2010. BMC Pregnancy and Childbirth. 2016;16(1):16-26. DOI:10.1186/ s12884-016-0820-4

Giraldo HJU, Betancur MAQ, García LAR, Merchán CAG, Grisales JCB. Controversias sobre el uso de micronutrientes. Rev Méd Risaralda. 2009;15(2):43-52

Sedjo RL, Neuhouser ML, Rock CL. Dietary Supplements and Cancer Risk: Epidemiologic Research and Recommendations. Preventive Nutrition: Springer; 2015: 183-214.

Tulchinsky TH. Micronutrient deficiency conditions: global health issues. Public Health Rev. 2010;32(1):243

Nakashima A, Yokoyama K, Yokoo T, Urashima M. Role of vitamin D in diabetes mellitus and chronic kidney disease. World J Diabetes. 2016;7(5):89-100. DOI:10.4239/wjd.v7.i5.89

Dudorova EY, Damulin IV, Khatkov IE. Neurological complications due to vitamin deficiencies after bariatric surgery. Ter Arkh. 2015;87(12):117-21

Folope V, Coeffier M, Dechelotte P. Nutritional deficiencies associated with bariatric surgery. Gastroenterol Clin Biol. 2007;31(4):369-77

Ulrich C, Potter J, Ulrich N. Folate supplementation: Too much of a good thing? Cancer Epidemiol Biomarkers Prev. 2006;15(2):189-93.

Bailey RL, Gahche JJ, Lentino CV, Dwyer JT, Engel JS, Thomas PR, et al. Dietary supplement use in the United States, 2003-2006. J Nutr. 2011;141(2):261-6.

Foote JA, Murphy SP, Wilkens LR, Hankin JH, Henderson BE, Kolonel LN. Factors Associated with Dietary Supplement Use among Healthy Adults of Five Ethnicities: he Multiethnic Cohort Study. Am J Epidemiol. 2003;157(10):888-97.

O’Keefe JH, Bergman N, Carrera-Bastos P, Fontes-Villalba M, DiNicolantonio JJ, Cordain L. Nutritional strategies for skeletal and cardiovascular health: hard bones, soft arteries, rather than vice versa. Open Heart. 2016 Mar 22;3(1):e000325. PubMed PMID: 27042317.

Skeie G, Braaten T, Hjartåker A, Lentjes M, Amiano P, Jakszyn P, et al. Use of dietary supplements in the European Prospective Investigation into Cancer and Nutrition calibration study. Eur J Clin Nutr. 2009;63(4):226-38.

Park SY, Kim YJ, Lee SY, Lee JG, Hwang HR, Jeong DW, et al. Vitamin-Mineral Supplement Use Patterns in Elderly Koreans: Data from the 2007–2008 Korean National Health and Nutrition Examination Survey. Korean J Fam Med. 2016;37(2):123-9.

Kantor ED, Rehm CD, Du M, White E, Giovannucci EL. Trends in dietary supplement use among US adults from 1999-2012. JAMA. 2016;316(14):1464-74.

Bailey RL, Gahche JJ, Miller PE, Thomas PR, Dwyer JT. Why US adults use dietary supplements. JAMA Intern Med. 2013;173(5):355-61.

Picciano MF, Dwyer JT, Radimer KL, Wilson DH, Fisher KD, Thomas PR, et al. Dietary supplement use among infants, children, and adolescents in the United States, 999-2002. Arch Pediatr Adolesc Med. 2007;161(10):978-85.

World Health Organization. Guidelines for ATC classification and DDD assignment [Internet] Geneve, 2017. [cited June/2017] Available:ttps://www.whocc.no/atc_ddd_index/.

Loza Santamaría E. Suplementos de calcio y vitamina D ¿para todos?: Contras [IV Simposio de Patologías Metabólicas Óseas]. Reumatol Clín . 2011;7(2):40-5.

Holguín-Hernández E, Orozco-Díaz JG. Administración de ácido fólico y otros micronutrientes en mujeres embarazadas de Colombia. Rev Panam Salud Pública. 2013;34(2):99-106.

Wong EC, Rose CE, Flores AL, Yeung LF. Trends in Multivitamin Use Among Women of Reproductive Age: United States, 2006- 2016. J Womens Health (Larchmt). 2019;28(1):37-45.

Ministerio de Salud y Protección Social. Guía de Práctica Clínica, detección temprana y tratamiento del embarazo, parto o puerperio [Internet]. Bogotá, 2013. [citado en Junio/2017]. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/ BibliotecaDigital/RIDE/INEC/IETS/GuC3%ADa. completa. Embarazo.Parto.2013.pdf.


Organización Mundial de la Salud. Directriz: Administración diaria de suplementos de hierro y ácido fólico en el embarazo [Internet]. Ginebra, 2014. [citado en une/2017] Disponible en: http://apps.who.int/iris/bitstream/10665/124650/1/9789243501994_spa.pdf.

Castellanos-Sinco HB, Ramos-Peñafiel CO, Santoyo-Sánchez A, Collazo-Jaloma J, Martínez-Murillo C, Montaño-Figueroa E, et al. Megaloblastic anaemia: Folic acid and vitamin B12 metabolism. Rev Méd Hosp Gen Méx. 2015;78(3):135-43.

Green R, Datta Mitra A. Megaloblastic Anemias: Nutritional and Other Causes. Med Clin North Am. 2017;101(2):297-317.

Percy L, Mansour D, Fraser I. Iron deficiency and iron deficiency anaemia in women. Best Pract Res Clin Obstet Gynaecol. 2017;40:55-67.

Hemilä H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013 Jan 31;(1):CD000980. PubMed PMID: 23440782.

Martini L, Pecoraro L, Salvottini C, Piacentini G, Atkinson R, Pietrobelli A. Appropriate and inappropriate vitamin supplementation in children. J Nutr Sci. 2020;9:e20.

Maher RL, Hanlon JT, Hajjar ER. Clinical Consequences of Polypharmacy in Elderly. Expert Opin Drug Saf. 2014;13(1):57-65.

Valavanidis A. Dietary supplements: Beneficial to human health or just peace of mind? A critical review on the issue of benefit/ risk of dietary supplements. Pharmakeftiki. 2016;28(2):60-83.

Machado-Alba J, Valencia-Marulanda J, Jiménez-Canizales C, Salazar V, Romero D. Patrones de prescripción de hormonas tiroideas en una población colombiana. Rev Panam Salud Pública. 2014;36(2):80-6.

Machado Alba JE, Moncada Escobar JC, Mesa Escobar G. Patrones de prescripción de antidiabéticos en un grupo de pacientes colombianos. Rev Panam Salud Pública. 2007;22(2):124-31
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