Keywords
Hemosiderosis
Chest radiography
Anemia
Dyspnea
Tomography
Chest radiography
Anemia
Dyspnea
Tomography
How to Cite
Muñoz Durán, J. A., & Muñoz Durán, A. F. (2020). Imaging findings of idiopathic pulmonary hemosiderosis in adults: Literature review of the last 20 years. Médicas UIS, 33(2), 55–64. https://doi.org/10.18273/revmed.v33n2-2020010
Abstract
Idiopathic pulmonary hemosiderosis is a rare entity characterized by capillary alveolar hemorrhage. Its classic triad is chronic or recurrent hemoptysis, iron deficiency anemia, and opacities in lung images. The objective of this review was to determine the frequency in chest radiography and chest tomography of the findings of idiopathic pulmonary hemosiderosis in adults, reported in the literature during the last 20 years, according to the semiological imaging findings, location and distribution. A search of publications in databases was made. Forty-two studies were collected, variables were stratified in different categories and the findings were compiled. The most frequent finding in chest radiography were consolidation and reticulonodular opacities. On the other hand, the main finding in tomography was ground glass opacities in the basal region. There were no differences in the pattern of compromise by gender, although women tended to have a more diffuse distribution. MÉD.UIS.2020;33(2):55-64.
References
Agarwal R, Aggarwal AN, Gupta D. Lane-Hamilton syndrome: simultaneous occurrence of coeliac disease and idiopathicpulmonary haemosiderosis. Intern Med J. 2007;37(1):65–7.
Khorashadi L, Wu C, Betancourt S, Carter B. Idiopathic pulmonary haemosiderosis: spectrum of thoracic imaging findings in the adult patient. Clinical Radiology. 2015;70(5):459–65.
Ioachimescu OC, Sieber S, Kotch A. Idiopathic pulmonary haemosiderosis revisited. Eur Respir J. 2004;24(1):162–70.
Fleischner FG, Berenberg AL. Idiopathic pulmonary hemosiderosis. Radiology. 1954;62(4):522–6.
Gencer M, Ceylan E, Bitiren M, Koc A. Two sisters with idiopathic pulmonary hemosiderosis. Can Respir J. 2007;14(8):490–3.
Berger N, Nichols J, Datta D. Idiopathic pulmonary haemosiderosis with celiac disease (Lane-Hamilton syndrome) in an adult - a case report. Clin Respir J. 2015;10(5):661–5.
Yanagihara T, Yamamoto Y, Hamada N, Suzuki K, Ogata-Suetsugu S, Harada E, et al. Recurrent idiopathic pulmonary hemosiderosis after long-term remission presented with Sjogren’s syndrome: Idiopathic no more? Respir Med Case Rep. 2018;25: 68–72.
Patiño S, Moncada DC, Ramírez JD. Hemosiderosis pulmonar idiopática en paciente adulto. Acta Med Colomb. 2017;42(1):64-7.
Silva P, Ferreira PG. Idiopathic pulmonary hemosiderosis: Hemorrhagic flare after 6 years of remission. Rev Port Pneumol. 2017;23(6):368–73.
Popp A, Jurcut C, Vasile D, Sotcan M,Laurila K, Jinga M. Severe Alveolar Hemorrhage – What’s in it for the Gastroenterologist? JGLD. 2016;25(4):555–8.
Barrera AM, Vargas L. Idiopathic pulmonary hemosiderosis with dendriform pulmonary dossification. Biomédica.2016;36(4):504.
Cambruzzi E, Pêgas KL, Vedana T. Idiopathic pulmonary hemorrhage: morphology and differential diagnosis. Case report J Bras Patol Med Lab. 2013;49(3):216–21.
Patrucco F, Sarcoli M, Boldorini R, Balbo PE. a young man with anemia and recurrent tachyarrhythmic episodes. Respiration. 2013;86(2):149–154.
Törő K, Herjavecz I, Vereckei E, Kovács M. Fatal idiopathic pulmonary haemosiderosis in association with pregnancy – medico-legal evaluation. J Forensic Leg Med. 012;19(2):101-4.
Santos JWAD, Neto ABDM, Marchiori RC, Michel GT, Fagundes AL, Tagliari LGM, et al. Hemossiderose pulmonar associada à doença celíaca: melhora após dieta livre de glúten. J Bras Pneumol. 2012;38(3):412-4.
Miwa S, Imokawa S, Kato M, Ide K, Uchiyama H, Yokomura K, et al. Prognosis in adult patients with idiopathic pulmonary hemosiderosis. Intern Med. 2011;50(17):1803–8.
Lang L,Wang X,Hou W. Successful treatment of adult idiopathic pulmonary hemosiderosis with integrated traditional Chineseand Western medicine: a report of one case. J Integr Med. 2011;9(5):5312.
Persson HL, Vainikka LK, Eriksson HB, Wennerström U. Lane- Hamilton syndrome: ferritin protects lung macrophages against iron and oxidation. Chest. 011;139(2):361–7.
Oviedo Ramírez MI, Hop K, Carrera E, Soriano Rosas J. Hemosiderosis pulmonar idiopática en un adulto joven. Hallazgos de autopsia. Arch Bronconeumol. 2010;46(10):565–7.
Krumsiek A, Poggemann V, Wertzel H, Achenbach HJ. Rezidivierende Hämoptysen bei einer 29-jährigen Patientin. Der Internist. 2010;51: 1561–6.
Robles M, Torres J, Rojas A. Tratamiento anestésico para cesárea electiva en una paciente con hemosiderosis pulmonar idiopática. Rev Esp Anestesiol Reanim. 2009;56(9): 577–8.
Mu XD, Su L, Nie LG, Na J, Wang RG, Li HC. Idiopathic pulmonary hemosiderosis in adults: report of two cases and literature review. Beijing Da Xue Xue Bao Yi Xue Ban. 2008;40(6): 595–9.
Harte S, Mcnicholas WT, Donnelly SC, Dodd JD. Honeycomb cysts in idiopathic pulmonary haemosiderosis: high-resolution CT appearances in two adults. B J Radiol. 2008;81(972): e295–8.
Foglia LM, Deering SH, Foglia LM, Deering SH. Post-partum exacerbation of idiopathic pulmonary hemosiderosis. J Matern Fetal Neonatal Med. 2008;21(12): 895–7.
Souza BV de, Schwingel FL, D’ Aquino LC. Hemosiderose pulmonar idiopática: exacerbação associada à gestação. Rev Soc Bras Clín Méd 2008;6(4): 160–2.
Mayes DH, Guerrero ML. A few good men: a marine with hemoptysis and diarrhea. idiopathic pulmonary hemosiderosis and celiac sprue. Chest. 2008;134(3):644–7.
Allen TK, George RB, Peterson-Layne C, Habib AS. Management of a parturient with an acute exacerbation of idiopathic pulmonary haemosiderosis and posterior spinal instrumentation. Br J Anaesth. 2008;100(2): 235–9.
Chen C-H, Yang H-B, Chiang S-R, Wang PC. Idiopathic pulmonary hemosiderosis: favorable response to corticosteroids. J Chin Med Asoc. 2008;71(8) 421–4.
Inayama M, Hino H, Takezaki A, Otsuka S, Machida H, Hatakeyam N, et al. A case of adult onset idiopathic pulmonaryhemosiderosis markedly improved by steroid herapy. Nihon Kokyuki Gakkai Zasshi. 2007; 45(12):971–6.
Deniz O, Ongürü O, Ors F, Gümüş S, Tozkoparan E, Bilgiç H, et al. Idiopathic pulmonary hemosiderosis in an adult patient responded well to corticosteroid therapy. Tuberk Toraks. 2007; 55(1):77–82.
Vinodh BN, Sharma SK, Mukhopadhyay S, Ray R. Idiopathic pulmonary haemosiderosis: two case reports. Indian J Chest Dis Allied Sci. 2006;48(1): 75–7.
Ioachimescu OC, Jennings C. Intercostal lung cyst hernia in idiopathic pulmonary hemosiderosis (cyst necessitans). Mayo Clinic Proc. 2006;81(5): 692.
Malhotra P, Aggarwal R, Aggarwal AN, Jindal SK, Awasthi A, Radotra BD. Coeliac disease as a cause of unusually severe anaemia in a young man with idiopathic ulmonary haemosiderosis. Respir Med. 2005;99(4):451–3.
Soto RG, Soares MM. Idiopathic pulmonary hemosiderosis in pregnancy: anesthetic implications. J Clin Anesth. 2005;17(6): 482–4.
Maalej S, Drira I, Fennira H, Ben Mefteh R, Bourguiba M, Zidi A, et al. Hémosidérose pulmonaire idiopathique de l’adulte. Rev Pneumol Clin. 2005; 61(2):109–11.
uray UY, Ergün P, Erdoğan Y, Biber C, Demirağ F, Keyf IA. Idiopathic pulmonary haemosiderosis. Tuberk Toraks 2004; 52(4):382–5.
Helman DL, Sullivan A, Kariya ST, Deering SH, Hueppchen NA, Shorr AF. Management of idiopathic pulmonary haemosiderosis in pregnancy: Report of two cases. Respirology. 2003; 8(3):398– 400.
Calabrese F, Giacometti C, Rea F, Loy M, Sartori F, Di Vittorio G, et al. Recurrence of idiopathic pulmonary hemosiderosis in a young adult patient after bilateral single-lung transplantation. Transplantation. 2002;74(11):1643–5.
Tedeschi A, Lorini M, Giannini S, Ciceri L, Suli C, Airaghi L. Serum histamine-releasing activity in a patient with idiopathic pulmonary haemosiderosis. Allergol Immunopathol (Madr). 2001;29(6):281–3.
Kishimoto N, Kondou H. A case of idiopathic pulmonary hemosiderosis of adult onset. Nihon Kokyuki Gakkai Zasshi. 2000;38(8):589–93.
Ruchin P, Robinson J, Segasothy M, Morey F. Melioidosis in a patient with idiopathic pulmonary haemosiderosis resident in Central Australia. Aust N Z J Med. 000;30(3):395–6.
Godoy I, Leite RM, Yoo HH, Defaveri J, Catâneo AJ, Queluz TH. Idiopathic pulmonary hemosiderosis with cystic lesions: a rare presentation. Am J Med Sci. 000;319(6):411–3.
Bavry AA, Knoper S, Alpert JS. Segmental Wall Motion Abnormalities in an Individual with Idiopathic Pulmonary Hemosiderosis. Cardiology. 2000;93(3):201-4.
amírez T, Prados C, Gómez de Terreros Caro J, Villamor J, Álvarez-Sala R. Hemosiderosis pulmonar idiopática en paciente de edad avanzada. Arch Bronconeumol. 999;35(10):507–9.
Hansell DM, Bankier AA, MacMahon H, McLoud TC, Müller NL, Remy J. Fleischner society: glossary of terms for thoracic imaging. 2008; 246(3):697-722.
Webb WR, Higgins CB. Thoracic Imaging: Pulmonary and Cardiovascular Radiology. 3rd ed. Wolters Kluwer; 2016.
Khorashadi L, Wu CC, Betancourt SL, Carter BW. Idiopathicpulmonary haemosiderosis: spectrum of thoracic imaging findings in the adult patient. Clin Radiol. 2015; 70(5):459–65.
Chen X-Y, Sun J-M, Huang X-J. Idiopathic pulmonary hemosiderosis in adults: review of cases reported in the latest 15 years: Idiopathic pulmonary hemosiderosis in adults. Clin Respir J. 2017;11(6):677–81
Khorashadi L, Wu C, Betancourt S, Carter B. Idiopathic pulmonary haemosiderosis: spectrum of thoracic imaging findings in the adult patient. Clinical Radiology. 2015;70(5):459–65.
Ioachimescu OC, Sieber S, Kotch A. Idiopathic pulmonary haemosiderosis revisited. Eur Respir J. 2004;24(1):162–70.
Fleischner FG, Berenberg AL. Idiopathic pulmonary hemosiderosis. Radiology. 1954;62(4):522–6.
Gencer M, Ceylan E, Bitiren M, Koc A. Two sisters with idiopathic pulmonary hemosiderosis. Can Respir J. 2007;14(8):490–3.
Berger N, Nichols J, Datta D. Idiopathic pulmonary haemosiderosis with celiac disease (Lane-Hamilton syndrome) in an adult - a case report. Clin Respir J. 2015;10(5):661–5.
Yanagihara T, Yamamoto Y, Hamada N, Suzuki K, Ogata-Suetsugu S, Harada E, et al. Recurrent idiopathic pulmonary hemosiderosis after long-term remission presented with Sjogren’s syndrome: Idiopathic no more? Respir Med Case Rep. 2018;25: 68–72.
Patiño S, Moncada DC, Ramírez JD. Hemosiderosis pulmonar idiopática en paciente adulto. Acta Med Colomb. 2017;42(1):64-7.
Silva P, Ferreira PG. Idiopathic pulmonary hemosiderosis: Hemorrhagic flare after 6 years of remission. Rev Port Pneumol. 2017;23(6):368–73.
Popp A, Jurcut C, Vasile D, Sotcan M,Laurila K, Jinga M. Severe Alveolar Hemorrhage – What’s in it for the Gastroenterologist? JGLD. 2016;25(4):555–8.
Barrera AM, Vargas L. Idiopathic pulmonary hemosiderosis with dendriform pulmonary dossification. Biomédica.2016;36(4):504.
Cambruzzi E, Pêgas KL, Vedana T. Idiopathic pulmonary hemorrhage: morphology and differential diagnosis. Case report J Bras Patol Med Lab. 2013;49(3):216–21.
Patrucco F, Sarcoli M, Boldorini R, Balbo PE. a young man with anemia and recurrent tachyarrhythmic episodes. Respiration. 2013;86(2):149–154.
Törő K, Herjavecz I, Vereckei E, Kovács M. Fatal idiopathic pulmonary haemosiderosis in association with pregnancy – medico-legal evaluation. J Forensic Leg Med. 012;19(2):101-4.
Santos JWAD, Neto ABDM, Marchiori RC, Michel GT, Fagundes AL, Tagliari LGM, et al. Hemossiderose pulmonar associada à doença celíaca: melhora após dieta livre de glúten. J Bras Pneumol. 2012;38(3):412-4.
Miwa S, Imokawa S, Kato M, Ide K, Uchiyama H, Yokomura K, et al. Prognosis in adult patients with idiopathic pulmonary hemosiderosis. Intern Med. 2011;50(17):1803–8.
Lang L,Wang X,Hou W. Successful treatment of adult idiopathic pulmonary hemosiderosis with integrated traditional Chineseand Western medicine: a report of one case. J Integr Med. 2011;9(5):5312.
Persson HL, Vainikka LK, Eriksson HB, Wennerström U. Lane- Hamilton syndrome: ferritin protects lung macrophages against iron and oxidation. Chest. 011;139(2):361–7.
Oviedo Ramírez MI, Hop K, Carrera E, Soriano Rosas J. Hemosiderosis pulmonar idiopática en un adulto joven. Hallazgos de autopsia. Arch Bronconeumol. 2010;46(10):565–7.
Krumsiek A, Poggemann V, Wertzel H, Achenbach HJ. Rezidivierende Hämoptysen bei einer 29-jährigen Patientin. Der Internist. 2010;51: 1561–6.
Robles M, Torres J, Rojas A. Tratamiento anestésico para cesárea electiva en una paciente con hemosiderosis pulmonar idiopática. Rev Esp Anestesiol Reanim. 2009;56(9): 577–8.
Mu XD, Su L, Nie LG, Na J, Wang RG, Li HC. Idiopathic pulmonary hemosiderosis in adults: report of two cases and literature review. Beijing Da Xue Xue Bao Yi Xue Ban. 2008;40(6): 595–9.
Harte S, Mcnicholas WT, Donnelly SC, Dodd JD. Honeycomb cysts in idiopathic pulmonary haemosiderosis: high-resolution CT appearances in two adults. B J Radiol. 2008;81(972): e295–8.
Foglia LM, Deering SH, Foglia LM, Deering SH. Post-partum exacerbation of idiopathic pulmonary hemosiderosis. J Matern Fetal Neonatal Med. 2008;21(12): 895–7.
Souza BV de, Schwingel FL, D’ Aquino LC. Hemosiderose pulmonar idiopática: exacerbação associada à gestação. Rev Soc Bras Clín Méd 2008;6(4): 160–2.
Mayes DH, Guerrero ML. A few good men: a marine with hemoptysis and diarrhea. idiopathic pulmonary hemosiderosis and celiac sprue. Chest. 2008;134(3):644–7.
Allen TK, George RB, Peterson-Layne C, Habib AS. Management of a parturient with an acute exacerbation of idiopathic pulmonary haemosiderosis and posterior spinal instrumentation. Br J Anaesth. 2008;100(2): 235–9.
Chen C-H, Yang H-B, Chiang S-R, Wang PC. Idiopathic pulmonary hemosiderosis: favorable response to corticosteroids. J Chin Med Asoc. 2008;71(8) 421–4.
Inayama M, Hino H, Takezaki A, Otsuka S, Machida H, Hatakeyam N, et al. A case of adult onset idiopathic pulmonaryhemosiderosis markedly improved by steroid herapy. Nihon Kokyuki Gakkai Zasshi. 2007; 45(12):971–6.
Deniz O, Ongürü O, Ors F, Gümüş S, Tozkoparan E, Bilgiç H, et al. Idiopathic pulmonary hemosiderosis in an adult patient responded well to corticosteroid therapy. Tuberk Toraks. 2007; 55(1):77–82.
Vinodh BN, Sharma SK, Mukhopadhyay S, Ray R. Idiopathic pulmonary haemosiderosis: two case reports. Indian J Chest Dis Allied Sci. 2006;48(1): 75–7.
Ioachimescu OC, Jennings C. Intercostal lung cyst hernia in idiopathic pulmonary hemosiderosis (cyst necessitans). Mayo Clinic Proc. 2006;81(5): 692.
Malhotra P, Aggarwal R, Aggarwal AN, Jindal SK, Awasthi A, Radotra BD. Coeliac disease as a cause of unusually severe anaemia in a young man with idiopathic ulmonary haemosiderosis. Respir Med. 2005;99(4):451–3.
Soto RG, Soares MM. Idiopathic pulmonary hemosiderosis in pregnancy: anesthetic implications. J Clin Anesth. 2005;17(6): 482–4.
Maalej S, Drira I, Fennira H, Ben Mefteh R, Bourguiba M, Zidi A, et al. Hémosidérose pulmonaire idiopathique de l’adulte. Rev Pneumol Clin. 2005; 61(2):109–11.
uray UY, Ergün P, Erdoğan Y, Biber C, Demirağ F, Keyf IA. Idiopathic pulmonary haemosiderosis. Tuberk Toraks 2004; 52(4):382–5.
Helman DL, Sullivan A, Kariya ST, Deering SH, Hueppchen NA, Shorr AF. Management of idiopathic pulmonary haemosiderosis in pregnancy: Report of two cases. Respirology. 2003; 8(3):398– 400.
Calabrese F, Giacometti C, Rea F, Loy M, Sartori F, Di Vittorio G, et al. Recurrence of idiopathic pulmonary hemosiderosis in a young adult patient after bilateral single-lung transplantation. Transplantation. 2002;74(11):1643–5.
Tedeschi A, Lorini M, Giannini S, Ciceri L, Suli C, Airaghi L. Serum histamine-releasing activity in a patient with idiopathic pulmonary haemosiderosis. Allergol Immunopathol (Madr). 2001;29(6):281–3.
Kishimoto N, Kondou H. A case of idiopathic pulmonary hemosiderosis of adult onset. Nihon Kokyuki Gakkai Zasshi. 2000;38(8):589–93.
Ruchin P, Robinson J, Segasothy M, Morey F. Melioidosis in a patient with idiopathic pulmonary haemosiderosis resident in Central Australia. Aust N Z J Med. 000;30(3):395–6.
Godoy I, Leite RM, Yoo HH, Defaveri J, Catâneo AJ, Queluz TH. Idiopathic pulmonary hemosiderosis with cystic lesions: a rare presentation. Am J Med Sci. 000;319(6):411–3.
Bavry AA, Knoper S, Alpert JS. Segmental Wall Motion Abnormalities in an Individual with Idiopathic Pulmonary Hemosiderosis. Cardiology. 2000;93(3):201-4.
amírez T, Prados C, Gómez de Terreros Caro J, Villamor J, Álvarez-Sala R. Hemosiderosis pulmonar idiopática en paciente de edad avanzada. Arch Bronconeumol. 999;35(10):507–9.
Hansell DM, Bankier AA, MacMahon H, McLoud TC, Müller NL, Remy J. Fleischner society: glossary of terms for thoracic imaging. 2008; 246(3):697-722.
Webb WR, Higgins CB. Thoracic Imaging: Pulmonary and Cardiovascular Radiology. 3rd ed. Wolters Kluwer; 2016.
Khorashadi L, Wu CC, Betancourt SL, Carter BW. Idiopathicpulmonary haemosiderosis: spectrum of thoracic imaging findings in the adult patient. Clin Radiol. 2015; 70(5):459–65.
Chen X-Y, Sun J-M, Huang X-J. Idiopathic pulmonary hemosiderosis in adults: review of cases reported in the latest 15 years: Idiopathic pulmonary hemosiderosis in adults. Clin Respir J. 2017;11(6):677–81
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