Keywords
Epigenetics
Fetal development
Nonalcoholic fatty liver disease
DNA methylation
How to Cite
Abstract
Pediatric non-alcoholic fatty liver disease is related to adverse pregnancy events that promote a modulation of differential methylation processes in the fetus. The objective of this research was to review the existing information provided by research on differential methylation processes that occur in fetal programming and that are regulated by exposure to gestational obesity. A review was carried out in the PubMed database with the inclusion of randomized clinical trials, systematic reviews, and subject reviews, related to the methylation processes that predispose to non-alcoholic fatty liver disease at an early age due to fetal exposure to maternal obesity. The evidence reports significant changes in the differential methylation processes related to the genetic expression of the children of obese mothers. These changes have an important capacity to program a predisposition to the development of this pathology.
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