Keywords
Tumor sólido
Metástasis de la Neoplasia
Reacción Leucoeritroblástica
How to Cite
Abstract
Introducción: En los últimos años, el interés en la invasión de médula ósea por células malignas no hematológicas ha
aumentado debido a la creciente evidencia que sugiere un impacto pronóstico en ciertos tipos de tumores sólidos. Sin
embargo, los datos disponibles sobre la fuente primaria de metástasis son escasos. Objetivo: sintetizar los datos reportados
sobre tumores no hematológicos infiltrantes de médula ósea en estudios basados en la confirmación histopatológica de
metástasis. Metodología: Se utilizó PubMed/Medline y Google Scholar; los filtros utilizados fueron estudios en humanos,
edad adulta (>14 años) y el período entre 1990-2021. El principal criterio de inclusión fue la confirmación histopatológica de
invasión de médula ósea. Los criterios de exclusión fueron informes de casos pequeños, criterios de neoplasia específicos y
series de casos agrupadas en literatura secundaria. Tres investigadores diferentes evaluaron todos los títulos y resúmenes
disponibles. Dos investigadores registraron datos de forma independiente. Finalmente, los datos se presentaron en
tablas utilizando estadística descriptiva. Resultados: Se incluyeron 31 artículos de 12 países; cuatro fueron multicéntricos y
todos menos 2 fueron retrospectivos. Se encontraron mil cuatrocientos cincuenta y un pacientes adultos con Metástasis
en Médula Ósea por tumores sólidos. Todos los estudios incluidos presentaron la distribución de la fuente primaria de
metástasis: el 82 % fueron neoplasias epiteliales, el 14 % fueron tumores de origen primario desconocido y el 10 % fueron
neoplasias específicas de baja frecuencia agrupadas como “otros”. Conclusión: Los resultados pueden considerarse con
cautela debido a la heterogeneidad metodológica de los estudios y el riesgo de sesgo.
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