Abstract
Acute kidney injury following the use of hair straightening products is a clinical entity poorly studied in the medical literature. These products may contain or release formaldehyde, even if marketed as formaldehyde-free, which can have cytotoxic effects on the kidney and trigger adverse immune responses. We present the case of an 18-year-old female patient with a history of arterial hypertension who developed KDIGO stage 3 acute kidney injury after using one of these products. A renal biopsy was performed, which revealed acute tubulointerstitial nephritis, tubular damage and oxalate crystals. After ruling out other possible causes, it was concluded that the renal injury was a complication directly related to exposure to these products. Given the lack of regulation in their composition, it is essential that physicians be aware of the potential adverse health effects associated with their use.
References
Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. United States. Kidney Int Suppl; 2012. https:// kdigo.org/wp-content/uploads/2016/10/KDIGO- 2012-AKI-Guideline-English.pdf
Perazella MA. Drug-induced nephropathy: an update. Expert Opin Drug Saf. 2005;4(4):689– 706.
Awdishu L, Mehta RL. The 6R’s of drug induced nephrotoxicity. BMC Nephrol. 2017;18(1):124.
Barnett LMA, Cummings BS. Nephrotoxicity and Renal Pathophysiology: A Contemporary Perspective. Toxicol Sci. 2018;164(2):379–390.
Peteffi GP, Antunes MV, Carrer C, Valandro ET, Santos S, Glaeser J, et al. Environmental and biological monitoring of occupational formaldehyde exposure resulting from the use of products for hair straightening. Environ Sci Pollut Res. 2016;23(1):908–917.
Asare-Donkor NK, Kusi Appiah J, Torve V, Voegborlo RB, Adimado AA. Formaldehyde Exposure and Its Potential Health Risk in Some Beauty Salons in Kumasi Metropolis. J Toxicol. 2020;2020:1–10.
Makuvara Z, Marumure J, Simbanegavi TT, Machingura J, Chaukura N, Gwenzi W. Unveiling the dark side of beauty? Beauty parlours as potential pollution and human exposure hotspots. Process Saf Environ Prot. 2024;182:1153–1170.
Ahmed HM, Rashad SH, Ismail W. Acute Kidney Injury Following Usage of Formaldehyde-Free Hair Straightening Products. Iran J Kidney Dis. 2019;13(2):129-131.
Bnaya A, Abu-Amer N, Beckerman P, Volkov A, Cohen-Hagai K, Greenberg M, et al. Acute Kidney Injury and Hair-Straightening Products: A Case Series. Am J Kidney Dis. 2023;82(1):43-52.
Instituto Nacional de Vigilancia en Medicamentos y Alimentos. Cosméticos. Bogota: Minsalud; 2022.
Occupational Safety and Health Administration. “Keratin-Based” Hair Smoothing Products And the Presence of Formaldehyde. Oregon: A Division of the Oregon Department of Consumer and Business Services and CROET at Oregon Health & Sciences University; 2010.
Abu-Amer N, Silberstein N, Kunin M, Mini S, Beckerman P. Acute Kidney Injury following Exposure to Formaldehyde-Free Hair- Straightening Products. Case Rep Nephrol Dial. 2022;12(2):112-116.
Schnedler N, Burckhardt G, Burckhardt BC. Glyoxylate is a substrate of the sulfate-oxalate exchanger, sat-1, and increases its expression in HepG2 cells. J Hepatol. 2011;54(3):513-520.
Aglan MA, Mansour GN. Hair straightening products and the risk of occupational formaldehyde exposure in hairstylists. Drug Chem Toxicol. 2020;43(5):488-495.
Dong Shen, Dasgupta PK. Solubility of gaseous formaldehyde in liquid water and generation of trace standard gaseous formaldehyde. Environ Sci Technol. 1986;20(6):637-640.
Starr TB, Gibson JE. The mechanistic toxicology of formaldehyde and its implications for quantitative risk estimation. Annu Rev Pharmacol Toxicol. 1985;25(1):745-76.
Boj JR, Marco I, Cortés O, Canalda C. The acute nephrotoxicity of systemically administered formaldehyde in rats. Eur J Paediatr Dent. 2003;4(1):16-20.
Inker LA, Astor BC, Fox CH, Isakova T, Lash JP, Peralta CA, et al. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD. Am J Kidney Dis. 2014;63(5):713-735.
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