Nefrotoxicidad inducida por medicamentos
Vol. 24 No. 1 (2011), Topic Review
Vol. 24 No. 1 (2011)

Nefrotoxicidad inducida por medicamentos

Topic Review
Published 2011-04-26
Carlos Alberto Calderón-Ospina
Universidad del Rosario
Ginna Melissa Guzmán-Ramírez
Universidad del Rosario
Juan Camilo Sarmiento-Monroy
Universidad del Rosario
Danney Loreyni Gómez-Angulo
Angélica Yasmín Joya-Higuera
Luisa Fernanda Ríos-Barajas
Jenny Paola Romero-Soler
Katiana Victoria Rosado-Sierra
Jenyffer Nathalie Soler-Barrera
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How to Cite

Calderón-Ospina, C. A., Guzmán-Ramírez, G. M., Sarmiento-Monroy, J. C., Gómez-Angulo, D. L., Joya-Higuera, A. Y., Ríos-Barajas, L. F., Romero-Soler, J. P., Rosado-Sierra, K. V., & Soler-Barrera, J. N. (2011). Nefrotoxicidad inducida por medicamentos. Médicas UIS, 24(1). Retrieved from https://revistas.uis.edu.co/index.php/revistamedicasuis/article/view/2583
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Abstract

 

Drug-induced nephrotoxicityThis review includes a description of the different types of drug-induced nephrotoxicity (DIN) according to histopathologicclassification, generation mechanism, clinical presentation and drugs most frequently involved. For this review, a systematicsearch was conducted in the Index Medicus for articles published since 1999, which were selected according to their relevance.The DIN is a finding of major clinical importance due to their high frequency and potential severity, and the lack of preventivemeasures in many cases. The main renal impairments caused by drugs can be classified histopathologically according toaltered renal function. Thus, there is the acute tubular necrosis, interstitial nephritis, glomerular injury and vascular changesthat in turn include thrombotic microangiopathy, atherosclerosis and vasculitis. Finally, some commonly used drugs with highpotential for nephrotoxicity are reviewed, with emphasis on recommendations for clinical use to optimize the renal safety ofthese products.

Key words: Drug toxicity. Kidney. Acute renal injury. Chronic renal insufficiency. Medicamentous disease. Secondary effect.

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