Palabras clave
Solid Tumor
Neoplasm Metastasis
Leukoerythroblastic reaction
Cómo citar
Resumen
Introduction: In recent years, scientific interest in bone marrow invasion or infiltration by non-hematological malignant
cells has increased due to growing evidence suggesting a prognostic impact in certain specific types of solid tumors.
However, the available data on the primary source of metastasis are scarce. Objective: synthesize the reported data on
non-hematological tumors infiltrating the bone marrow in studies based on histopathological confirmation of metastases.
Methodology: PubMed/Medline and Google Scholar were used for the systematic review; the filters used were human
studies, adult age (>14 years old), and the period between 1990-2021. The main inclusion criteria was the histopathological
confirmation of bone marrow invasion. The exclusion criteria were small case reports, specific neoplasm criteria, and grouped case series in secondary literature to minimize bias. Three different researchers evaluated all the titles and abstracts available. Two researchers independently extracted and recorded data; this process was cross-checked again. Finally, data were summarized and presented in tables using descriptive statistics. Results: 31 articles from 12 countries were included; four were multicenter, and all but 2 were retrospective. One thousand four hundred fifty-one adult patients with Bone Marrow Metastasis due to solid tumors were found. All included studies presented the distribution of the primary source of metastases: 82 % were epithelial neoplasms, 14 % were tumors of unknown primary origin, and 10 % were low-frequency specific neoplasms grouped as ‘others’. Conclusion: The results can be considered with caution due to the methodological heterogeneity of the studies and the risk of bias.
Referencias
Jonsson U, Rundles RW. Tumor Metastases in Bone Marrow. Blood. 1951;6(1):16-25.
Kaushansky K, Prchal JT, Burns LJ, Lichtman MA, Levi M, Linch DC. Williams Hematology. 10th ed. Columbus, Ohio: McGraw-Hill Education; 2021.
Zhang QY, Foucar K. Bone Marrow involvement by Hodgkin and Non-Hodgkin lymphomas. Hematol Oncol Clin North Am. 2009;23(4):873- 902.
Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F, et al. Lugano 2014 criteria for assessing FDG-PET/CT in lymphoma: an operational approach for clinical trials. Drug Des Devel Ther. 2017;11:1719–1728.
Widick P, Brunner AM, Schiffman F. Chapter 155 - Hematologic Manifestations of Malignancy. In: Hoffman R, Benz EJ, Silberstein LE, Heslop HE, Weitz JI, Anastasi J, Salama ME, Abutalib SA, editors. Hematology: Basic Principles and Practice. 7th Edition. Elsevier; 2018. p. 2247-2252.
Bussard KM, Gay CV, Mastro AM. The bone microenvironment in metastasis; what is special about bone?. Cancer Metastasis Rev 2008;27(1):41-55.
Kelleher MT, Kendall A, Chowdhury S. Bone Marrow carcinosis and disseminated tumour cells. Onkologie. 2010;33(1-2):7-9.
Chen F, Han Y, Kang Y. Bone marrow niches in the regulation of bone metastasis. Br J Cancer. 2021;124(12):1912-1920.
Høilund-Carlsen PF, Hess S, Werner TJ, Alavi A. Cancer metastasizes to the bone marrow and not to the bone: time for a paradigm shift!. Eur J Nucl Med Mol Imaging. 2018;45(6):893-897.
National Comprehensive Cancer Network [Internet]. Plymouth Meeting: NCCN. NCCN history [cited 2023 Feb 6]. Available from: https://www.nccn.org/home/about/nccn-history
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: International Agency for Research on Cancer; 2017.
Chou WC, Yeh KY, Peng MT, Chen JS, Wang HM, Lin YC, et al. Development and Validation of a Prognostic Score to Predict Survival in Adult Patients with Solid Tumors and Bone Marrow Metastases. Medicine (Baltimore). 2015;94(23): e966.
Luján M, Cardona AF, Yepes A, Carrasco E, Revéiz L, Brugés R. Myelophthisis Old aspects, new concepts. Acta Med Colomb. 2009;34(4):169-175.
Hung YS, Chou WC, Chen TD, Chen TC, Wang PN, Chang H, et al. Prognostic factors in adult patients with solid cancers and bone marrow metastases. Asian Pac J Cancer Prev. 2014;15(1):61-67.
Rani HS, Hui M, Manasa PL, Uppin SG, Uppin MS, Paul TR, et al. Bone Marrow Metastasis of Solid Tumors: A Study of 174 Cases Over 2 Decades from a Single Institution in India. Indian J Hematol Blood Transfus. 2022;38(1):8-14.
Kilickap S, Erman M, Dincer M, Aksoy S, Harputluoglu H, Yalcin S. Bone marrow metastasis in solid tumors: Clinical evaluation of 64 cases. J Clin Oncol. 2005;23(16_suppl):8270–8270.
Filanovsky K, Feldberg E, Miller EB, Shvidel L. Predictive Value of Clinical and Laboratory Parameters for Overt Bone Marrow Metastasis in Patients with Solid Malignancy. J Cancer Ther. 2017;08(08):773-784.
Krishnan C, George TI, Arber DA. Bone Marrow Metastases: A Survey of Nonhematologic Metastases with Immunohistochemical Study of Metastatic Carcinomas. Appl Immunohistochem Mol Morphol. 2007;15(1):1-7.
Aksoy S, Kilickap S, Hayran M, et al. Platelet size has diagnostic predictive value for bone marrow metastasis in patients with solid tumors. Int J Lab Hematol. 2008;30(3):214-219.
Xiao L, Luxi S, Ying T, Yizhi L, Lingyun W, Quan P. Diagnosis of unknown nonhematological tumors by bone marrow biopsy: a retrospective analysis of 10,112 samples. J Cancer Res Clin Oncol. 2009;135(5):687-693.
Kucukzeybek BB, Calli AO, Kucukzeybek Y, Bener S, Dere Y, Dirican A, et al. The prognostic significance of bone marrow metastases: Evaluation of 58 cases. Indian J Pathol Microbiol. 2014;57(3):396.
Moid F, DePalma L. Comparison of Relative Value of Bone Marrow Aspirates and Bone Marrow Trephine Biopsies in the Diagnosis of Solid Tumor Metastasis and Hodgkin Lymphoma: Institutional Experience and Literature Review. Arch Pathol Lab Med. 2005;129(4):497-501.
Brahmbhatt B, Parikh B, Shah M. Bone Marrow involvement by Metastatic solid Tumors. IMA GSB. 2014;9(8):54-57.
Loayza N. Entidades nosológicas asociadas a mieloptisis. Rev Mex Patol Clin. 1999;46(2):107.
Yun HK, Shin MG, Bo D, Kim DW, Cho D, Shin JH, et al. Laboratory evaluation of bone marrow metastasis: single institute study. Korean J Lab Med. 2007;27(2):96-101.
Gahlot GP, Ahuja A, Baranwal AK, Madhukar G, Asthana B, Chatterjee T, et al. Original Article Non-Hematological Malignancies Seeding in Bone Marrow. Ann Pathol Lab Med. 2020;7(7): A341-48.
Mehdi SR, Bhatt ML. Metastasis of Solid Tumors in Bone Marrow: A Study from Northern India. Indian J Hematol Blood Transfus . 2011;27(2):93- 95. Available from: http://link.springer. com/10.1007/s12288-011-0069-z
Zhou MH, Wang ZH, Zhou HW, Liu M, Gu YJ, Sun JZ. Clinical outcome of 30 patients with bone marrow metastases. J Cancer Res Ther . 2018;14(9):S512-15.
Aytan P, Kocer NE, Yeral M, Gereklioglu C, Kasar M, Buyukkurt NH, et al. Non-Hematologic Malignancies Metastasing to the Bone Marrow: A Record-Based Descriptive Study from A Tertiary Center. Int J Hematol Oncol]. 2019;29(4):238- 245.
Jalaly F, Ojha S, Ashraf M, Jain R, Sawke N. Bone Marrow Involvement in Non-Hematological Malignancy: A Clinico-pathological Study from a Tertiary Hospital. Ann Pathol Lab Med. 2018;5(5): A440-446.
Rudresha AH, Patidar R, Lakshmaiah KC, Babu KG, Lokanatha D, Jacob LA, et al. Pattern of Bone Marrow Involvement by Solid Tumors: Experience from a Tertiary Care Center from South India. Indian J Med Paediatr Oncol . 2019;40(1):S99-101.
Wong KF, Chan JK, Ma SK. Solid tumour with initial presentation in the bone marrow—a clinicopathologic study of 25 adult cases. Hematol Oncol . 1993;11(1):35-42.
Chandra S, Chandra H, Saini S. Bone marrow metastasis by solid tumors—probable hematological indicators and comparison of bone marrow aspirate, touch imprint and trephine biopsy. Hematology . 2010;15(5):368- 372.
Syed NN, Moiz B, Adil SN, Khurshid M. Diagnostic importance of bone marrow examination in non-hematological disorders. J Pak Med Assoc. 2007;57(3):123-125.
Tyagi R, Singh A, Garg B, Sood N. Beware of Bone Marrow: Incidental Detection and Primary Diagnosis of Solid Tumours in Bone Marrow Aspiration and Biopsies; A Study of 22 Cases. Iran J Pathol. 2018;13(1):78-84.
Ozkalemkas F, Ali R, Ozkocaman V, Ozcelik T, Ozan U, Ozturk H, et al. The bone marrow aspirate and biopsy in the diagnosis of unsuspected nonhematologic malignancy: A clinical study of 19 cases. BMC Cancer. 2005;5(1):144.
Kumar V, Sardana R, Kishore M, Marwah S, Nigam AS, Bhardwaj M. Bone Marrow Cytomorphology And Clinico-Hematological Profile of Metastatic Solid Tumors: A 5-Year Audit from A Tertiary Care Centre in Northern India. Ann Pathol Lab Med. 2019;6(3):129-134.
Chauhan K, Jain M, Grover S, Shukla P, Rusia U, Grover R. Bone marrow metastasis in nonhematologic malignancies: Data from a cancer hospital. Clin Cancer Investig J. 2016;5(2):103-109.
Mishra P, Das S, Kar R, Jacob SE, Basu D. Non-haematopoietic malignancies metastasing to the bone marrow: a 5 year record-based descriptive study from a tertiary care centre in South India. Indian J Cancer. 2014;51(1):30-34.
Nusrat Bashir, Tazeen Jeelani, Bilal Musharaf , Ruby Reshi , Nausrat Ali AB. Metastasis of solid tumors into bone marrow: An experience from a tertiary care centre. Int J Med Sci Innov Res. 2018;3(3):250-255.
Hamid GA, Hanbala N. Comparison of bone marrow aspiration and bone marrow biopsy in neoplastic diseases. Gulf J Oncolog. 2009;(6):41-4.
Kołda A, Helbig G, Kopińska A, Wichary R, Pająk J, Kyrcz-Krzemień S. Metastasis of solid tumors into bone marrow - Single center experience. Acta Haematol. 2017;48(2):130–4.
Høilund-Carlsen PF, Hess S, Werner TJ, Alavi A. Cancer metastasizes to the bone marrow and not to the bone: time for a paradigm shift!. Eur J Nucl Med Mol Imaging. 2018;45(6):893–7.
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7-33.
Cotta CV, Konoplev S, Medeiros LJ, Bueso-Ramos CE. Metastatic tumors in bone marrow: histopathology and advances in the biology of the tumor cells and bone marrow environment. Ann Diagn Pathol. 2006;10(3):169–92.
Papac RJ. Bone marrow metastases. A review. Cancer 1994;74(9):2403–2413.
Ulloa Pérez V, Ruiz Gil W, Barrantes Alarcón CA. Significado clínico de la punción seca de médula ósea o “Dry tap”. Rev méd hered. 1997;8(2):50– 57.
Takemoto C, Nishiuchi R, Endo C, Oda M, Seino Y. Comparison of two methods for evaluating bone marrow metastasis of neuroblastoma: Reverse transcription-polymerase chain reaction for tyrosine hydroxylase and magnetic resonance imaging. Pediatr Int. 2004;46(4):387–393.
Acosta M, Pereira J, Arroz M. Screening of carcinoma metastasis by flow cytometry: A study of 238 cases. Cytometry B Clin Cytom. 2016;90(3):289–294.
Ciancia R, Martinelli V, Cosentini E, Picardi M, Petruzziello F, Matano E, et al. High number of circulating CD34+ cells in patients with myelophthisis. Haematologica. 2005;90(7):976– 977.
Calvache ET, Calvache ADT, Faulhaber GAM. Systematic review about etiologic association to the leukoerythroblastic reaction. Int J Lab Hematol . 2020;42(5):495–500.
Sheikhbahaei S, Jones KM, Werner RA, Salas-Fragomeni RA, Marcus CV, Higuchi T. et al. 18 F-NaF-PET/CT for the detection of bone metastasis in prostate cancer: a meta-analysis of diagnostic accuracy studies. Ann Nucl Med. 2019;33(5):351-161.
Al-Muqbel KM. Bone Marrow Metastasis is an Early Stage of Bone Metastasis in Breast Cancer Detected Clinically by F18-FDG-PET/CT Imaging. Biomed Res Int. 2017;9852632.
Evangelista L, Panunzio A, Polverosi R, Ferretti A, Chondrogiannis S, Pomerri F, et al. Early bone marrow metastasis detection: The additional value of FDG-PET/CT vs. CT imaging. Biomed Pharmacother. 2012;66(6):448–453.
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Derechos de autor 2023 Médicas UIS