Seminoma type extragonadal germ cell tumor in mediastinum. Case report
PDF (Español (España))

Keywords

Neoplasms
Mediastinal Neoplasms
Neoplasms, Germ Cell and Embryonal
Seminoma
Superior Vena Cava Syndrome

How to Cite

Alquichire-Luna, C. A., & Otero-Álvarez, A. C. (2023). Seminoma type extragonadal germ cell tumor in mediastinum. Case report. Médicas UIS, 36(3), 139–144. https://doi.org/10.18273/revmed.v36n3-2023013

Abstract

Extragonadal presentation of germ cell tumors represent 5 to 7 % of this type, mainly in young men. Due to its low incidence
globally, it represents a diagnostic challenge in clinical practice. We present the case of a young adult male patient with no
associated history, who consulted to a level III institution, due to exacerbation of symptoms of four months of evolution
characterized by chest pain, syndrome of superior vena cava, cervical adenopathies and constitutional syndrome. Imaging
identified a mediastinal mass that was subjected to histopathological studies for samples obtained in thoracotomy,
allowing the diagnosis of mediastinal seminoma and eventually treatment with chemoradiotherapy to be initiated. The
importance of interdisciplinary work at hospital leves is emphasized , linking paraclinical, radiological and histopathological
aids, to adequately identify this type of neoplasm as it presents a diagnostic challenge.

https://doi.org/10.18273/revmed.v36n3-2023013
PDF (Español (España))

References

Billmire DF. Germ cell tumors. Surg Clin North Am. 2006;86(2):489-503.

Weissferdt A, Rodriguez-Canales J, Liu H, Fujimoto J, Wistuba II, Moran CA. Primary mediastinal seminomas: a comprehensive immunohistochemical study with a focus on novel markers. Hum Pathol. 2015;46(3):376-383.

Vallejo-Yepes C, Beltrán R, Buitrago R, Brugés R, Carvajal Fierro CA, Carreño Dueñas JA, Beltrán J. Características clínicas y desenlaces de supervivencia en pacientes con tumores de células germinales de primario mediastinal, atendidos en el instituto nacional de cancerología entre 2008 y 2020 [tesis]. Bogotá, Colombia: Universidad El Bosque; 2021.

Newton ATM. Tumores del Mediastino. Ponencia presentada en: 61° Congreso Argentino de Cirugía Torácica. Sociedad Argentina de Cirugía Torácica. 2017; Argentina: Hospital de Clínicas J. de San Martín.

Hernández-Benedicto R, Pila-Pérez R, Rosales-Torres P. Tumor de células germinales primario de mediastino (seminoma de mediastino). Arch. méd. Camagüey. 2019;23(1):95-103.

Daliakopoulos SI, Stergianni M, Karagkiouzis G, Koutela A, Pappas D, Tsakalakis C, et al. Primary malignant Germ-Cell tumors of the anterior

mediastinum in adults. Report of two rare cases and review of the literature. MOJ Clin Med Case Rep. 2019;9(3):68-74.

Soledispa-Navarrete KM, Villalta-Barreto ME, Suárez-Bacilio AM, García-Arteaga MF. Seminoma Mediastinal. RECIMUNDO. 2022;6(1): 78-86.

Bishop MA, Kyriakopoulos C. Mediastinal Seminoma. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.

Marom EM. Advances in thymoma imaging. J Thorac Imaging. 2013;28(2):69-80.

Beyer J, Albers P, Altena R, Aparicio J, Bokemeyer C, Busch J, et al. Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer. Ann Oncol. 2013;24(4):878-88.

Takahashi K, Al-Janabi NJ. Computed tomography and magnetic resonance imaging of mediastinal tumors. J Magn Reson Imaging. 2010;32(6):1325-39.

Salinas-Cisneros G, Basadre-Quiro C, Carranza-Gajardo E, Gallo-Guerrero M, Montenegro-Guerraud X. Tumor de mediastino anterior en un paciente varón de 28 años. Reporte de caso y revisión de la literatura. Rev Horiz Med. 2012;12(1):50-56.

Scheckel CJ, Kosiorek HE, Butterfield R, Ho TH, Hilal T. Germ Cell Tumors with Malignant Somatic Transformation: A Mayo Clinic Experience. [published correction appears in Oncol Res Treat. 2019;42(6):354]. Oncol Res Treat. 2019;42(3):95-100.

Napieralska A, Majewski W, Osewski W, Miszczyk L. Primary mediastinal seminoma. J Thorac Dis. 2018;10(7):4335-4341.

Huang W, Luo J, Zhou X, Zhao Y, Zhang T, Ma X. Nomograms for Predicting Prognosis of Primary Mediastinal Seminoma: A Population-Based Study. J Oncol. 2021;2021:9048375.

Weissferdt A, Suster S, Moran CA. Primary mediastinal "thymic" seminomas. Adv Anat Pathol. 2012;19(2):75-80.

Holmes C, Loo PS, Barnard S. Primary mediastinal seminoma with florid follicular lymphoid hyperplasia: a case report and review of the literature. Diagn Pathol. 2021; 16(1):76-84.

Shi D, Chen C, Huang H, Tian J, Zhou J, Jin S. Primary seminoma of prostate in a patient with Klinefelter syndrome: A case report. Medicine (Baltimore). 2022;101(17):e29117.

Alrabeeah K, Alothman A, Alhajress G, Al Oudah N, Alnasser NA, Alkhayal A. Intraoperative diagnosis of seminoma in a man with cryptorchidism and Klinefelter Syndrome planning for m-TESE: A case report. 2022; 44:102149.

Marandino L, Vogl UM. Mediastinal germ cell tumours: where we are and where we are going-a narrative review. Mediastinum. 2022; 6:7.

Viera M, Pinto MA, Menéndez ML, Sifontes Y. Presentación de un caso de seminoma mediastinal. Revista cubana de medicina. 2011; 5(4):458-464.

Petrova D, Kraleva S, Muratovska L, Crcareva B. Primary Seminoma Localized in Mediastinum: Case Report. Open Access Maced J Med Sci. 2019; 7(3):384-387.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2023 Médicas UIS

Downloads

Download data is not yet available.