Abstract
Ischemic stroke constitutes a fundamental health issue due to its high level of recurrence. Developing effcient and safe strategies to prevent vascular episodes in patients with ischemic stroke must be a top priority, with the purpose of diminishing associated mortality and disability. Several studies have examined combined antithrombotic therapy in depth, trying to improve its effcacy in secondary prevention of vascular events after a frst ischemic stroke. This work reviews the current state of clinical evidence related to combined antithrombotic therapy in patients presenting a frst ischemic stroke.
Key words. Ischemic stroke. Secondary prevention. Antithrombotics. Antiplatelets. Anticoagulation.
References
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2.Wu CM, McLaughlin K, Lorenzetti DL, Hill MD, Manns BJ, Ghali WA. Early risk of stroke after transient ischemic attack: a systematic review and meta-analysis. Arch Intern Med 2007;167(22):2417-22.
3.Clark TG, Murphy MF, Rothwell PM., Touzé E, Varenne O, Chatellier G, et al. Risk of myocardial infarction and vascular death after transient ischemic attack and ischemic stroke: a systematic review and meta-analysis. Stroke 2005;36(12):2748-55
4.Correia M, Silva MR, Magalhes R, Guimarães L, Silva MC. Transient ischemic attacks in rural and urban northern Portugal: incidence and short-term prognosis. Stroke 2006;37(1):50-5.
5.Clark TG, Murphy MF, Rothwell PM. Long term risks of stroke, myocardial infarction, and vascular death in “low risk” patients with a non-recent transient ischaemic attack. J Neurol Neurosurg Psychiatry 2003;74(5):577-80.
6.Purroy F, Montaner J, Molina CA, Delgado P, Ribo M, Alvarez-Sabín J. Patterns and predictors of early risk of recurrence after transient ischemic attack with respect to etiologic subtypes. Stroke 2007;38(12):3225-9.
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