Multimorbidity and clinical results of a pediatric population with suspected COVID-19 treated in a Mexican hospital
PDF (Español (España))

How to Cite

Albavera-Hernández, C., Rodríguez-Rojas, S., Barreto-Toledano, E. J., Rivera-Neri, Y. E., Quezada-Herrera, A., Díaz-León, L. D., Amaro-Leal, D. A., Juárez-Valerio, A. B., Mendoza-Garcés, V. J., Paz-García, A. L., Santos-Castrejón, Óscar R., Toledo-Chávez, A., Meneses-Arcos, O. R., Gómez-Anayansi, R., Pinto-Álvarez, M., Ávila-Jiménez, L., & Rodríguez-Hernández, J. M. (2022). Multimorbidity and clinical results of a pediatric population with suspected COVID-19 treated in a Mexican hospital. Salud UIS, 54. https://doi.org/10.18273/saluduis.54.e:22023

Abstract

Introduction: Data from several countries around the world suggest that children with COVID-19 may present different and less severe symptoms than adults. However, the epidemiological and clinical patterns in this population group have been unclear. Methods: This is an observational study, with an initial cross-analytical characterization, and with a longitudinal or follow-up component in a group of minors with suspected and or confirmed case of COVID-19, which have outcomes such as improvement, transfer to a higher level of care or death due to respiratory symptoms. The children received medical attention at the Regional General Hospital with Family Medicine No 1 (HGR C / MF No 1), and underwent a Real Time Polymerase Chain Reaction test (RT-PCR). Results: 98 children were studied as suspected cases for COVID-19, who underwent RT-PCR. Of the total 24 were positive and 74 were negatives. The median age was 64.4 months (0 to 203 months), 55 minors were male, 59 children had outpatient management, and of these 14 had a positive result. Among those who required hospital management (39), 10 children were positive for SARS-CoV-2, y 84.7% achieved improvement and were discharged. Four were transferred to a higher level of care hospital. Of the 98 children in the study 11 died, seven had a negative result and four a positive result for SARS-CoV-2. Conclusions: The main symptoms of the pediatric population in this study were; fever, cough and general discomfort. Four of those who died had a positive result for SARS-CoV-2; however, they had other comorbidities.

https://doi.org/10.18273/saluduis.54.e:22023
PDF (Español (España))

References

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382(8): 727-733. doi: https://doi.org/10.1056/NEJMoa2001017

Aragón-Nogales R, Vargas-Almanza I, Miranda-Novales MG. COVID-19 por SARS-CoV-2: la nueva emergencia de salud. Rev Mex Pediatr. 2019; 86(6): 213-218.

Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel Coronavirus–infected pneumonia. N Engl J Med. 2020; 382(13): 1199-1207. doi: https://doi.org/10.1056/NEJMoa2001316

Dong Y, Dong Y, Mo X, Hu Y, Qi X, Jiang F, et al. Epidemiology of COVID-19 among children in China. 2020; 145(6): e20200702. Pediatrics. doi: https://doi.org/10.1542/peds.2020-0702

Calvo C, García López-Hortelano M, de Carlos Vicente JC, Vázquez Martínez JL, Ramos JT, Baquero-Artigao F, et al. Recommendations on the clinical management of the COVID-19 infection by the «new coronavirus» SARS-CoV2. Spanish Paediatric Association working group. An Pediatr. 2020; 92(4): 241.e1-241.e11. doi: https://doi.org/10.1016/j.anpedi.2020.02.001

Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nature Rev Microbiol. 2019; 17: 181-192. doi: https://doi.org/10.1038/s41579-018-0118-9

Organización Panamericana de la Salud / Organización Mundial de la Salud. Actualización Epidemiológica Enfermedad por coronavirus. OMS/OPS. 2020;1-11.

Gobierno de Mexico. Comunicado técnico diario COVID-19 MEXICO. Mexico; 2020; https://www.gob.mx/cms/uploads/attachment/file/551325/Comunicado_Tecnico_Diario_COVID-19_2020.05.08.pdf

Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 Infection in children. N Engl J Med. 2020; 382(17): 1663-1665. doi: https://doi.org/10.1056/NEJMc2005073

Chang TH, Wu JL, Chang LY. Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis. J Formos Med Assoc. 2020; 119(5): 982-989. doi: https://doi.org/10.1016/j.jfma.2020.04.007

Update on COVID-19 epidemiology and impact on medical care in children. 2020. Canadian Paediatric Society. https://www.cps.ca/en/documents/position/update-on-covid-19-epidemiology-and-impact-on-medical-care-in-children-april-2020

Carlotti AP de C, de Carvalho WB, Johnston C, Rodriguez IS, Delgado AF. Covid-19 diagnostic and management protocol for pediatric patients. Clinics (Sao Paulo). 2020; 75: 1894. doi https://doi.org/10.6061/clinics/2020/e1894

De México, Gobierno. Datos Abiertos-Dirección General de Epidemiología. https://www.gob.mx/salud/documentos/datos-abiertos-152127

Tsankov BK, Allaire JM, Irvine MA, Lopez AA, Sauvé LJ, Vallance BA, et al. Severe COVID-19 Infection and pediatric comorbidities: a systematic review and meta-analysis. International J Infect Diseases. 2021; 103: 246-256. doi: https://doi.org/10.1016/j.ijid.2020.11.163

Steinman JB, Lum FM, Ho PPK, Kaminski N, Steinman L. Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics. Proceedings of the National Academy of Sciences. 2020; 117(40): 24620-24626. doi: https://doi.org/10.1073/pnas.2012358117

Dhochak N, Singhal T, Kabra SK, Lodha R. Pathophysiology of COVID-19: why children fare better than adults? Indian J Pediatr. 2020; 87(7): 537-546. doi: https://doi.org/10.1007/s12098-020-03322-y

Carsetti R, Quintarelli C, Quinti I, Piano Mortari E, Zumla A, Ippolito G, et al. The immune system of children: the key to understanding SARS-CoV-2 susceptibility? Lancet Child Adolesc Health. 2020; 4(6): 414-416. doi: https://doi.org/10.1016/S2352-4642(20)30135-8

Bunyavanich S, Do A, Vicencio A. Nasal gene expression of angiotensin-converting enzyme 2 in children and adults. Jama. 2020; 323(23): 2427-2429. doi: https://doi.org/10.1001/jama.2020.8707

Frenkel LD, Gómez F, Bellanti JA. COVID-19 in children: Pathogenesis and current status. Allergy Asthma Procs. 2021; 42(1): 8-15 doi: 10.2500/aap.2020.42.200104

Williams PCM, Howard-Jones AR, Hsu P, Palasanthiran P, Gray PE, McMullan BJ, et al. SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings. Pathology. 2020; 52(7): 801-808. doi: https://doi.org/10.1016/j.pathol.2020.08.001

Castagnoli R, Votto M, Licari A, Brambilla I, Bruno R, Perlini S, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents a systematic review. JAMA pediatrics. 2020; 174(9): 882-889. doi: https://doi.org/10.1001/jamapediatrics.2020.1467

Guía Operativa para el manejo Integral del paciente pediátrico con sospecha o confirmación de COVID-19. Funsalud 2022. https://funsalud.org.mx/guia-operativa-para-el-manejo-integral-del-paciente-pediatrico-con-sospecha-o-confirmacion-de-covid-19/

Cabrero-Hernández M, García-Salido A, Leoz-Gordillo I, Alonso-Cadenas JA, Gochi-Valdovinos A, González Brabin A, et al. Severe SARS-CoV-2 infection in children with suspected acute abdomen: a case series from a tertiary hospital in Spain. Pediatric Infect Dis J. 2020; 39(8): 195-1988. doi: https://doi.org/10.1097/INF.0000000000002777

Parri N, Lenge M, Buonsenso D. Children with Covid-19 in pediatric emergency departments in Italy. N Engl J Med. 2020; 383(2):187-90. doi: : https://doi.org/10.1056/NEJMc2007617

Tung Ho CL, Oligbu P, Ojubolamo O, Pervaiz M, Oligbu G. Clinical Characteristics of Children with COVID-19. AIMS Public Health. 2020; 7(2): 258-273. doi: https://doi.org/10.3934/publichealth.2020022

Zeng L, Xia S, Yuan W, Yan K, Xiao F, Shao J, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA Pediatrics. 2020; 174(7): 722-725. doi: 10.1001/jamapediatrics.2020.0878

Sola A, Maksimovic L, Montes MT, Rodríguez S, Cardetti M, Golombek S, et al. Sociedad Iberoameticana de Neonatología y COVID-19 perinatal: Información y recomendaciones de SIBEN. 2020. http://www.siben.net/images/htmleditor/files/covid19_perinatal_información_y_recomendaciones_de_siben.pdf

Bialek S, Gierke R, Hughes M, McNamara LA, Pilishvili T, Skoff T. Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020. MMWR Morb Mortal Wkly Rep. 2020; 69(14): 422-426. doi: http://dx.doi.org/10.15585/mmwr.mm6914e4

Godfred-Cato S, Bryant B, Leung J, Oster ME, Conklin L, Abrams J, et al. COVID-19–Associated Multisystem Inflammatory Syndrome in Children — United States, March–July 2020. MMWR Morb Mortal Wkly Rep. 2020; 69(32): 1074-1080. doi: http://dx.doi.org/10.15585/mmwr.mm6932e2

Yonker LM, Neilan AM, Bartsch Y, Patel AB, Regan J, Arya P, et al. Pediatric SARS-CoV-2: clinical presentation, infectivity, and immune responses. J Pediatr. 2020; 227: 45-52.e5. doi: https://doi.org/10.1016/j.jpeds.2020.08.037

Verdoni L, Mazza A, Gervasoni A, Martelli L, Ruggeri M, Ciuffreda M, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020; 395(10239): 1771-1778. doi: https://doi.org/10.1016/S0140-6736(20)31103-X

Riphagen S, Gómez X, González-Martínez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020; 395(10237): 1607-1608. doi: https://doi.org/10.1016/S0140-6736(20)31094-1

Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol. 2020; 20(6): 363-374. doi: https://doi.org/10.1038/s41577-020-0311-8

Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. 2020; 20(6): 689-696. doi: https://doi.org/10.1016/S1473-3099(20)30198-5

Watson J, Whiting PF, Brush JE. Interpreting a covid-19 test result. BMJ 2020; 369: m1808 doi: https://doi.org/10.1136/bmj.m1808

Parri N, Magistà AM, Marchetti F, Cantoni B, Arrighini A, Romanengo M, et al. Characteristic of COVID-19 infection in pediatric patients: early findings from two Italian Pediatric Research Networks. Eur J Pediatr. 2020; 179(8): 1315-1323. doi: https://doi.org/10.1007/s00431-020-03683-8

Dong Y, Dong Y, Mo X, Hu Y, Qi X, Jiang F, et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics. 2020; doi: https://doi.org/10.1542/peds.2020-0702

Götzinger F, Santiago-García B, Noguera-Julián A, Lanaspa M, Lancella L, Calò Carducci FI, et al. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health. 2020; 4(9): 653-661. doi: https://doi.org/10.1016/S2352-4642(20)30177-2

Parri N, Lenge M, Cantoni B, Arrighini A, Romanengo M, Urbino A, et al. COVID-19 in 17 Italian pediatric emergency departments. Pediatrics. 2020; 146(6): e20201235. doi: https://doi.org/10.1542/peds.2020-1235

Chiotos K, Bassiri H, Behrens EM, Blatz AM, Chang J, Diorio C, et al. Multisystem inflammatory syndrome in children during the coronavirus 2019 pandemic: a case series. J Pediatric Infect Dis Soc. 2020; 9(3): 393-398. doi: https://doi.org/10.1093/jpids/piaa069

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2022 Cidronio Albavera-Hernández, Sarahí Rodríguez-Rojas, Eloísa Janet Barreto-Toledano, Yurandir Elid Rivera-Neri, Anaí Quezada-Herrera, Laura Dolores Díaz-León, Diego Augusto Amaro-Leal, Ana Belén Juárez-Valerio, Verónica Jocelyn Mendoza-Garcés, Ana Laura Paz-García, Óscar Roberto Santos-Castrejón, Aurelia Toledo-Chávez, Oscar Raúl Meneses-Arcos, Ramón Gómez-Anayansi, Mariana Pinto-Álvarez, Laura Ávila-Jiménez, Jorge Martín Rodríguez-Hernández

Downloads

Download data is not yet available.