Keywords
HIV
Antiretroviral therapy
Colombia
How to Cite
Abstract
Introduction: adherence to drug treatment promotes viral suppression and reduces long-term resistance to highly active antiretroviral therapy (HAART). Objective: to determine the relationship between the pharmacological aspects and adherence to antiretroviral treatment in a Colombian IPS. Methodology: follow-up study with 9835 patients diagnosed with HIV on antiretroviral treatment between 2012 and 2020. A multiple binary logistic regression model was used for explanatory purposes. Results: the proportion of adherence was 90,04% and in the adjusted model assessed its relationship with history of non-adherence (ORa: 0,52 95% CI: 0,40-0,66), pharmacological group (2 NRTI + 1 PI or other) (ORa: 1,22 95% CI: 0,99-1,76), two doses per day (ORa: 1,02 95% CI: 0,74-1,40), units per day (≥ 3 ) (ORa: 0,69 95% CI: 0,47-1,02), adverse drug reactions (ORa: 0,56 95% CI: 0,40-0,78), polypharmacy (ORa: 1,36 95% CI : 1,00-1,85), ART time (1 to 2 years) (ORa: 1,63 95% CI: 1,27-2,09), ART time (6 to 12 months) (ORa: 1,66 95% CI: 1,27-2,18), ART time (<6 months) (ORa: 1,36 95% CI: 1,03-1,78), inconsistency in the claim (ORa: 0,42 95% CI: 0,32–0,55) and PRUM history (ORa: 0,11 95% CI: 0,09–0,14). Conclusion: the history of non-adherence, adverse reactions, inconsistencies in the claim and history of problems related to the use of medications are aspects that reduce the probability of adherence. While the longer time of use of the treatment increases adherence.
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Copyright (c) 2023 Carlos Alberto Gómez-Mercado, Juliana Madrigal-Cadavid, Alejandra Rendón-Montoya, Ana María Hincapié, Newar Andrés Giraldo-Alzate, Jorge Iván Estrada Acevedo, Paulo Andrés Giraldo-Sánchez, Juan Alberto Serna-Zuluaga