Coinfection by SARS-CoV-2 with other viruses in patients from health institutions in the department of Boyacá, 2021-2022
PDF (Español (España))

Keywords

Infection for SARS-CoV-2
Coinfection
Respiratory tract diseases
Virus
Influenza A Virus
Prevalence

How to Cite

Suescún-Carrero, S. H., Valdivieso-Bohórquez, S. J. ., Avila-Panche, S., Ucros-Alvarez, A., & Rolon-Rojas, M. J. (2024). Coinfection by SARS-CoV-2 with other viruses in patients from health institutions in the department of Boyacá, 2021-2022. Salud UIS, 56. https://doi.org/10.18273/saluduis.56.e:24041

Abstract

The pandemic due to the new coronavirus (SARS-CoV-2) has been an enormous challenge and problem for global public health. This virus is characterized by rapid human-human transmission through droplets and contact with respiratory secretions. This study aimed to identify the prevalence of coinfection of SARS-CoV-2 with other respiratory viruses in patients in hospitalization and outpatient services in the department of Boyacá. Cross-sectional observational study carried out on nasopharyngeal swab samples from patients diagnosed with COVID-19. In the period from August 2021 to August 2022, RT-qPCR and Panel FilmArray Respiratory were performed to determine the presence of 17 respiratory viruses. Sociodemographic and symptomatology data were collected. Univariate analysis was performed and the proportion of coinfection of SARS-CoV-2 with other viruses was calculated. For the bivariate analysis, Pearson’s Chi square was calculated. Statistical analyzes were performed with the SPSS statistical package. A total of 77 samples were included, 18,2% of the cases presented coinfection. The virus that occurred most frequently was influenza A with 49,9% followed by adenovirus, rhinovirus/enterovirus and coronavirus OC43, each with 14,2%. The most prevalent clinical manifestations were cough with 20,8%, fever 17,7% and dyspnea 20%. No significant differences were found between the clinical manifestations of patients with coinfection. The results obtained in the present study contribute to the surveillance system, knowledge of the coinfection of SARSCoV- 2 with other respiratory viruses in the department of Boyacá, for decision making and strengthening prevention policies.

https://doi.org/10.18273/saluduis.56.e:24041
PDF (Español (España))

References

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020; 382: 1708‐1720. doi: 10.1056/NEJMoa2002032

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020; 323(11): 1061– 1069. doi: 10.1001/jama.2020.1585

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; 395(10223): 507–513. doi:10.1016/S0140-6736(20)30211-7

PAHO. Monthly COVID-19 Epidemiological Update - Region of the Americas - 02 August 2023 - PAHO/WHO | Pan American Health Organization [Internet]. Washington D. C: PAHO; 2023. Disponible en: https://www.paho.org/en/documents/monthly-covid-19-epidemiologicalupdate-region-americas-02-august-2023

Instituto Nacional de Salud. Boletín epidemiológico. Bogotá: INS; 2023. Disponible en: https://www.ins.gov.co/buscador-eventos/BoletinEpidemiologico/2023_Bolet %C3 %ADn_epidemiologico_semana_26.pdf

Li Z, Chen ZM, Chen LD, Zhan YQ, Li SQ, Cheng J, et al. Coinfection with SARS-CoV-2 and other respiratory pathogens in patients with COVID-19 in Guangzhou, China. J. Med. Virol. 2020; 92(11): 2381-2383. doi: 10.1002/jmv.26073

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382(8): 727–733. doi: 10.1056/NEJMoa2001017

Suclupe-Campos D, Aguilar-Gamboa F. Fundamentos moleculares de la exclusión competitiva durante la coinfección de virus respiratorios: a propósito del COVID-19. Rev Cubana Hematol Inmunol Hemoter. 2021; 37: 1-24.

Chen X, Liao B, Cheng L, Peng X, Xu X, Li Y, et al. The microbial coinfection in COVID-19. J Appl Microbiol Biotechno. 2020; 104(18): 7777–7785. doi: 10.1007/s00253-020-10814-6

Malekifar P, Pakzad R, Shahbahrami R, Zandi M, Jafarpour A, Rezayat SA, et al. Viral Coinfection among COVID-19 Patient Groups: An Update Systematic Review and Meta-Analysis. BioMed research international. 2021; 5313832. doi: 10.1155/2021/5313832

Dante M, Quiñones L, Alonso S, Quilca-Barrera L, Valero I, Cruz V, et al. Frecuencia de coinfección por patógenos respiratorios y su impacto en el pronóstico de pacientes con COVID-19. Rev Fac Med Hum. 2021; 21(2): 610- 622. doi: 10.25176/RFMH.v21i3.3520

Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DK, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RTPCR. Euro Surveill. 2020; 25(3): 2000045. doi: 10.2807/1560-7917.ES.2020.25.3.2000045

Victoriano CM, Pask ME, Malofsky NA, Seegmiller A, Simmons S, Schmitz J. et al. Direct PCR with the CDC 2019 SARS-CoV-2 assay: optimization for limited-resource settings. Sci Rep. 2022; 12: 11756. doi: 10.1038/s41598-022-15356-7

Shen SS, Qu XY, Zhang WZ, Li J, L ZY. Infection against infection: parasite antagonism against parasites, viruses and bacteria. Infect Dis Poverty. 2019; 8(1): 49. doi: 10.1186/s40249-019-0560-6

Aguilar-Gamboa FR, Suclupe-Campos DO. Fundamentos moleculares de la exclusión competitiva durante la coinfección de virus respiratorios: a propósito del COVID-19. Rev Cubana Hematol Inmunol Hemoter. 2021; 37(Suppl 1): e1473.

Nowak MD, Sordillo EM, Gitman MR, Paniz-Mondolfi AE. Coinfection in SARS-CoV-2 infected patients: Where are influenza virus and rhinovirus/enterovirus?. J Med Virol. 2020; 92(10): 1699–1700. doi: 10.1002/jmv.25953

Kim D, Quinn J, Pinsky B, Shah NH, Brown I. Rates of Co-infection Between SARS-CoV-2 and Other Respiratory Pathogens. JAMA. 2020; 323(20): 2085-2086. doi: 10.1001/jama.2020.6266

Lin D, Liu L, Zhang M, Hu Y, Yang Q, Guo J, et al. Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected patients. Sci China Life Sci. 2020; 63(4): 606-609. doi: 10.1007/s11427-020-1668-5

Fernandes-Matano L, Monroy-Muñoz IE, Uribe-Noguez LA, Hernández-Cueto MD, Sarquiz-Martínez B, Pardavé-Alejandre HD, et al. Coinfecciones por SARS-CoV-2 y otros virus respiratorios y su desenlace clínico. Rev Med Inst Mex Seguro Soc. 2021; 59(6): 482-489.

Ma S, Lai X, Chen Z, Tu S, Qin K. Clinical characteristics of critically ill patients co-infected with SARS-CoV-2 and the influenza virus in Wuhan, China. Int J Infect Dis. 2020; 96: 683–687. doi: 10.1016/j.ijid.2020.05.068

Arguni E, Supriyati E, Hakim MS, Daniwijaya EW, Makrufardi F, Rahayu A, et al. Co-infection of SARS-CoV-2 with other viral respiratory pathogens in Yogyakarta, Indonesia: A cross-sectional study. Ann Surg. 2022; 77: 103676. doi: 10.1016/j.amsu.2022.103676

Jackson CB, Farzan M, Chen B, Choe H. Mechanisms of SARS-CoV-2 entry into cells. Nat Rev Mol Cell Biol. 2022; 23(1): 3-20. doi: 10.1038/s41580-021-00418-x

Dou D, Revol R, Östbye H, Wang H, Daniels R. Influenza a virus cell entry, replication, virion assembly and movement. Front Immunol. 2018; 9: 1581. doi: 10.3389/fimmu.2018.0158

Zhang AJ, Lee AC, Chan JF, Liu F, Li C, Chen Y, et al. Coinfection by severe acute respiratory syndrome Coronavirus 2 and Influenza A(H1N1) pdm09 virus enhances the severity of pneumonia in Golden Syrian hamsters. Clin Infect Dis. 2021; 72: e978–992. doi: 10.1093/cid/ciaa1747

Matera L, Manti S, Petrarca L, Pierangeli A, Conti MG, Mancino E, et al. An overview on viral interference during SARS-CoV-2 pandemic.Front Pediatr. 2023; 11: 1308105. doi: 10.3389/fped.2023.1308105

Ding Q, Lu P, Fan Y, Xia Y, Liu M. The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China. J Med Virol. 2020; 1-7. doi: 10.1002/jmv.25781

Ochani R, Asad A, Yasmin F, Shaikh S, Khalid H, Batra S, et al. COVID-19 pandemic: from origins to outcomes. A comprehensive review of viral pathogenesis, clinical manifestations, diagnostic evaluation, and management. Infez Med. 2021; 29(1): 20–36.

Zhang JJ, Dong X, Cao YY, Yuan YD, Yang YB, Yan YQ, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020; 75(7): 1730–1741. doi:10.1111/all.14238

Ozaras R, Cirpin R, Duran A, Duman H, Arslan O, Bakcan Y, et al. Influenza and COVID-19 coinfection: Report of six cases and review of the literature. J Med Virol. 2020; 1-9. doi:10.1002/jmv.26125

Pizzorno A, Padey B, Dulière V, Mouton W, Oliva J, Laurent E, et al. Interactions between severe acute respiratory syndrome coronavirus 2 replication and major respiratory viruses in human nasal epithelium. J Infect Dis. 2022; 226(12): 2095–2104. doi: 10.1093/infdis/jiac357

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2024 Sandra Helena Suescún-Carrero, Silvia Juliana Valdivieso-Bohórquez, Sandra ´Avila-Panche, Andrey Ucros-Alvarez, Maria Juliana Rolon-Rojas

Downloads

Download data is not yet available.