Keywords
reticulocytes
hypoxia
erythropoiesis
altitude
How to Cite
Abstract
Introduction: EPO is a glycosylated alpha globulin produced in more than 90% by kidneys through adult life, being a key hormone that regulated the erythrocytic mass; however, it exists some levels modification of this hormone related to smoking, anemia, EPOC and migration to from low to higher altitudes, which causes a hypoxic process. Depending on individuals it produces or not the so called acute mountain sickness. Objective: To describe erythropoietin level modifications, reticulocytes count and its influence in adaptive process to the altitude. Methodology: It is a transversal descriptive study which included 11 participants from low altitudes places who EPO seric concentration and reticulocytes count was determined during a 28 days period. Results: Eight participants presented a progressive increase in EPO seric levels, one participant showed a constant level and two more showed atypical results according with literature reported. Conclusion: The EPO is a key factor which determines the erythropoiesis beginning, its objective is to improve the oxygen provision in altitude adaptive process and increases its concentration in blood due to hypoxic stimulus; hypoxia is a determinant factor in the beginning and development of acute mountain sickness. The reticulocytes counting depends also from proliferative and antiapoptotic EPO stimulus by seric concentrations of B12 vitamin, iron and folic acid
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