Keywords
Triatoma dimidiata
Chagas disease
synthetic analogues of girgensohnine
Videomex V.
Chagas disease
synthetic analogues of girgensohnine
Videomex V.
How to Cite
Escobar, E., Carreño Otero, A., Kouznetsov, V., & Duque, J. (2018). Toxicity and affectation in locomotion of Triatoma dimidiata (Latreille 1811) (Hemiptera: Reduviidae: Triatominae) treated with analogues of girgensohnine. Salud UIS, 50(3), 205–213. https://doi.org/10.18273/revsal.v50n3-2018005
Abstract
Introduction: Analogs of the girgensohnine alkaloid, designed and synthesized to inhibit acetylcholinesterase enzyme, have presented an insecticidal effect on vectors insects of diseases. Objective: To determine the insecticidal activity of 12 synthetic analogs of gingersohnine in first stage nymphs of Triatoma dimidiata. Materials and methods: WHO protocol 2005, using exploratory doses, was used to determine the best molecule according to its mortality. First stage nymphs of T. dimidiata were exposed to different doses of the analogs by topical application and surface exposure. Lethal doses (LD50 and DL95) and alterations in locomotion using Videomex V software were determined. Results: Analog 6 presented the highest insecticidal activity at 72 h with a mortality of 20.8% ± 3.57 for topical treatment and 25%±0,0 for non-porous surfaces evaluation. Analog 6 lethal doses were LD50 1036.8 ± 0.38 ng and DL95 3991.4 ± 0.508 ng, respectively. With regard to locomotion, analogue 6 induced a similar behavior to that observed for commercial insecticide deltametrin.
References
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9. Palomino M, Villaseca P, Cárdenas F, Ancca J, Pinto M. Eficacia y residualidad de dos insecticidas piretroides contra Triatoma infestans en tres tipos de viviendas. evaluación de campo en Arequipa, Perú. Rev Peru Med Exp Salud Publica. 2008; 25(1): 9-16.
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11. Mougabure-Cueto G, Picollo MI. Insecticide resistance in vector Chagas disease: Evolution, mechanisms and management. Acta Trop. 2015; 149: 70-85. doi: 10.1016/j.actatropica.2015.05.014.
12. Vargas LY, Kouznetsov VV. First Girgensohnine analogs prepared through InCl3 -catalyzed Strecker Reaction and their Bioprospection. Curr Org Synth. 2013; 10: 969-973.
13. Cuadros J, Carreño Otero A, Kouznetsov V, Duque JE. Insecticidal action of synthetic girgensohnine analogs and essential oils on Rhodnius prolixus (Hemiptera: Reduviidae). Biomed - Rev Inst Nac Salud. 2017; 37(2): 1-27.
14. Carreño Otero AL, Vargas Méndez LY, Duque LJE, Kouznetsov VV. Design, synthesis, acetylcholinesterase inhibition and larvicidal activity of girgensohnine analogs on Aedes aegypti, vector of dengue fever. Eur J Med Chem. 2014; 78: 392-400. doi: 10.1016/j.ejmech.2014.03.067.
15. Alzogaray, R. A. Behavioral and toxicological responses of Rhodnius prolixus (Hemiptera: Reduviidae) to the insect repellents DEET and IR3535. J Med Entomol. 2016; 53: 387-393. doi: 10.1093/jme/tjv194.
16. Reyes M, Angulo VM. Ciclo de vida de Triatoma dimidiata Latreille, 1811 ( Hemiptera, Reduviidae) en condiciones de laboratorio : producción de ninfas para ensayos biológicos. Biomedica. 2009; 1811: 119-126.
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19. Reyes M, Angulo VM, Sandoval CM. Efecto tóxico de β -cipermetrina , deltametrina y fenitrotión en cepas de Triatoma dimidiata (Latreille , 1811) y Triatoma maculata (Erichson, 1848) (Hemiptera, Reduviidae). Biomedica. 2007; 27(Supl. 1): 75-82.
20. Moretti AN, Seccacini EA, Zerba EN, Canale D, Alzogaray RA. The botanical monoterpenes linalool and eugenol flush-out nymphs of Triatoma infestans (Hemiptera: Reduviidae). J Med Entomol 2017; 54: 1293-1298.
21. Alzogaray RA, Fontán A, Zerba EN. Evaluation of hyperactivity produced by pyrethroid treatment on third instar nymphs of Triatoma infestans (Hemiptera:Reduviidae). Arch Insect Biochem Physiol. 1997; 35(3): 323-333. doi: 0.1002/(SICI)1520-6327(199705)35:3<323::AIDARCH6>3.0.CO;2-U.
22. PoloPc. POLO-Plus, POLO for Windows computer program, version 2.0. LeOra-Software, Petaluma, CA. 2007.
23. Sfara V, Zerba EN, Alzogaray RA. Toxicity ofpyrethroids and repellency of diethyltoluamide in
two deltamethrin-resistant colonies of Triatoma infestans Klug, 1834 (Hemiptera: Reduviidae). Mem Inst Oswaldo Cruz. 2006; 101(1): 89-94. doi: 10.1590/S0074-02762006000100017.
24. Carreño Otero AL, Palacio-Cortés AM, Navarro-Silva MA, Kouznetsov VV, Duque L. JE. Behavior of detoxifying enzymes of Aedes aegypti exposed to girgensohnine alkaloid analog and Cymbopogon flexuosus essential oil. Comp Biochem Physiol C Toxicol Pharmacol. 2018; 204: 14-25. doi: 10.1016/j.cbpc.2017.11.002.
25. Borrero Landazabal MA, Carreño Otero AL, Kouznetsov VV, Duque Luna JE, Mendez-Sanchez SC. Alterations of mitochondrial electron transport chain and oxidative stress induced by alkaloid-like α-aminonitriles on Aedes aegypti larvae. Pestic Biochem Physiol. 2018; 144: 64-70. doi: 10.1016/j.pestbp.2017.11.006.
26. Germano, M. D. Herencia y efectos demográficos de la resistencia a deltametrina en Triatoma infestans. Centro de Investigaciones de Plagas e Insecticidas. Buenos Aires, 2012; Tesis Doctoral.
27. Stampini M, Girgenti P, Locatelli DP. Activity of Deltamethrin on different surfaces against Plodia interpunctella larvae (Lepidoptera Pyralidae). Ist Entomol Agrar Univ Stud Milano. 2008; 1-6.
28. Palomino M, León W, Valencia P, Cárdenas F, Ancca J. Evaluación de campo del efecto residual de la Deltametrina sobre la mortalidad y knockdown en Triatoma infestans, según tipo de supeficie en Arequipa, Perú. Rev Per Med Exp Salud Publica. 2007; 24(2): 136-143.
29. Alzogaray R, Sfara V, Moretti AN, Zerba EN. Behavioural and toxicological responses of Blattella germanica (Dictyoptera: Blattellidae) to monoterpenes. Eur J Entomol. 2013; 110(2):
247-252.
30. Xuereb B, Lefèvre E, Garric J, Geffard O. Acetylcholinesterase activity in Gammarus fossarum (Crustacea Amphipoda): Linking AChE inhibition and behavioural alteration. Aquat
Toxicol. 2009; 94(2): 114-122. doi: 10.1016/j.aquatox.2009.06.010.
2. Sales Junior PA, Carneiro CM, Sánchez-Montalvá A, de Oliveira RC, Fonseca Murta SM, Salvador F. Experimental and clinical treatment of Chagas disease: a review. Am J Trop Med Hyg. 2017; 97(5): 1289-1303. doi: 10.4269/ajtmh.16-0761.
3. Reisenman CE, Lawrence G, Guerenstein PG, Gregory T, Dotson E, Hildebrand JG. Infection of kissing bugs with trypanosoma cruzi, Tucson, Arizona, USA. Emerg Infect Dis. 2010; 16(3): 400-405. doi: 10.3201/eid1603.090648.
4. Boiani M, Piacenza L, Hernández P, Boiani L, Cerecetto H, González M, et al. Mode of action of Nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: Is oxidative stress involved? Biochem Pharmacol. 2010; 79(12): 1736-1745. doi: 10.1016/j.bcp.2010.02.009.
5. Reyes-Novelo E, Ruiz-Piña HA, Escobedo-Ortegón J, Barrera-Pérez MA. Biología y ecología de Triatoma dimidiata (Latreille, 1811), algunos aspectos de estudio. Dugesiana. 2011;18(1):11-16.
6. Justi SA, Galvão C. The evolutionary origin of diversity in Chagas disease vectors. Trends Parasitol. 2017; 33(1): 42-52. doi: 10.1016/j.pt.2016.11.002.
7. Alzogaray R A. El control químico de Triatoma infestans en Argentina. Retel - Rev Toxicol Lin. 2003; 1: 1-18.
8. Guhl F, Aguilera G, Pinto NA, Vergara D. Actualización de la distribución geográfica y ecoepidemiología de la fauna de triatominos (Reduviidae: Triatominae) en Colombia. Biomédica.
2007; 27(1): 143-162.
9. Palomino M, Villaseca P, Cárdenas F, Ancca J, Pinto M. Eficacia y residualidad de dos insecticidas piretroides contra Triatoma infestans en tres tipos de viviendas. evaluación de campo en Arequipa, Perú. Rev Peru Med Exp Salud Publica. 2008; 25(1): 9-16.
10. Carneiro ÂP, Pereira MJ, Galbiati C. Biocide activity of Annona coriacea seeds extract on Rhodnius neglectus (Hemiptera: Reduviidae). Rev Biol Trop. 2013; 61(1): 419-427.
11. Mougabure-Cueto G, Picollo MI. Insecticide resistance in vector Chagas disease: Evolution, mechanisms and management. Acta Trop. 2015; 149: 70-85. doi: 10.1016/j.actatropica.2015.05.014.
12. Vargas LY, Kouznetsov VV. First Girgensohnine analogs prepared through InCl3 -catalyzed Strecker Reaction and their Bioprospection. Curr Org Synth. 2013; 10: 969-973.
13. Cuadros J, Carreño Otero A, Kouznetsov V, Duque JE. Insecticidal action of synthetic girgensohnine analogs and essential oils on Rhodnius prolixus (Hemiptera: Reduviidae). Biomed - Rev Inst Nac Salud. 2017; 37(2): 1-27.
14. Carreño Otero AL, Vargas Méndez LY, Duque LJE, Kouznetsov VV. Design, synthesis, acetylcholinesterase inhibition and larvicidal activity of girgensohnine analogs on Aedes aegypti, vector of dengue fever. Eur J Med Chem. 2014; 78: 392-400. doi: 10.1016/j.ejmech.2014.03.067.
15. Alzogaray, R. A. Behavioral and toxicological responses of Rhodnius prolixus (Hemiptera: Reduviidae) to the insect repellents DEET and IR3535. J Med Entomol. 2016; 53: 387-393. doi: 10.1093/jme/tjv194.
16. Reyes M, Angulo VM. Ciclo de vida de Triatoma dimidiata Latreille, 1811 ( Hemiptera, Reduviidae) en condiciones de laboratorio : producción de ninfas para ensayos biológicos. Biomedica. 2009; 1811: 119-126.
17. Robertson JL, Savin NE, Preisler HK, Russell RM. Bioassays with Arthropods, Second Ed. 2007; 102, 224.
18. World Health Organization - WHO. Report of the WHO informal consultation on the evaluation and testing of insecticides. 1996; 76.
19. Reyes M, Angulo VM, Sandoval CM. Efecto tóxico de β -cipermetrina , deltametrina y fenitrotión en cepas de Triatoma dimidiata (Latreille , 1811) y Triatoma maculata (Erichson, 1848) (Hemiptera, Reduviidae). Biomedica. 2007; 27(Supl. 1): 75-82.
20. Moretti AN, Seccacini EA, Zerba EN, Canale D, Alzogaray RA. The botanical monoterpenes linalool and eugenol flush-out nymphs of Triatoma infestans (Hemiptera: Reduviidae). J Med Entomol 2017; 54: 1293-1298.
21. Alzogaray RA, Fontán A, Zerba EN. Evaluation of hyperactivity produced by pyrethroid treatment on third instar nymphs of Triatoma infestans (Hemiptera:Reduviidae). Arch Insect Biochem Physiol. 1997; 35(3): 323-333. doi: 0.1002/(SICI)1520-6327(199705)35:3<323::AIDARCH6>3.0.CO;2-U.
22. PoloPc. POLO-Plus, POLO for Windows computer program, version 2.0. LeOra-Software, Petaluma, CA. 2007.
23. Sfara V, Zerba EN, Alzogaray RA. Toxicity ofpyrethroids and repellency of diethyltoluamide in
two deltamethrin-resistant colonies of Triatoma infestans Klug, 1834 (Hemiptera: Reduviidae). Mem Inst Oswaldo Cruz. 2006; 101(1): 89-94. doi: 10.1590/S0074-02762006000100017.
24. Carreño Otero AL, Palacio-Cortés AM, Navarro-Silva MA, Kouznetsov VV, Duque L. JE. Behavior of detoxifying enzymes of Aedes aegypti exposed to girgensohnine alkaloid analog and Cymbopogon flexuosus essential oil. Comp Biochem Physiol C Toxicol Pharmacol. 2018; 204: 14-25. doi: 10.1016/j.cbpc.2017.11.002.
25. Borrero Landazabal MA, Carreño Otero AL, Kouznetsov VV, Duque Luna JE, Mendez-Sanchez SC. Alterations of mitochondrial electron transport chain and oxidative stress induced by alkaloid-like α-aminonitriles on Aedes aegypti larvae. Pestic Biochem Physiol. 2018; 144: 64-70. doi: 10.1016/j.pestbp.2017.11.006.
26. Germano, M. D. Herencia y efectos demográficos de la resistencia a deltametrina en Triatoma infestans. Centro de Investigaciones de Plagas e Insecticidas. Buenos Aires, 2012; Tesis Doctoral.
27. Stampini M, Girgenti P, Locatelli DP. Activity of Deltamethrin on different surfaces against Plodia interpunctella larvae (Lepidoptera Pyralidae). Ist Entomol Agrar Univ Stud Milano. 2008; 1-6.
28. Palomino M, León W, Valencia P, Cárdenas F, Ancca J. Evaluación de campo del efecto residual de la Deltametrina sobre la mortalidad y knockdown en Triatoma infestans, según tipo de supeficie en Arequipa, Perú. Rev Per Med Exp Salud Publica. 2007; 24(2): 136-143.
29. Alzogaray R, Sfara V, Moretti AN, Zerba EN. Behavioural and toxicological responses of Blattella germanica (Dictyoptera: Blattellidae) to monoterpenes. Eur J Entomol. 2013; 110(2):
247-252.
30. Xuereb B, Lefèvre E, Garric J, Geffard O. Acetylcholinesterase activity in Gammarus fossarum (Crustacea Amphipoda): Linking AChE inhibition and behavioural alteration. Aquat
Toxicol. 2009; 94(2): 114-122. doi: 10.1016/j.aquatox.2009.06.010.
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