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Resumo
Introdução: o câncer escamocelular da cavidade oral é uma patologia com
baixas taxas de sobrevivência. Quando não é tratada adequadamente é um
tumor de alta recorrência e resistente ao tratamento. Novas hipóteses propõem
que as células tumorais progenitoras pelas suas propriedades de
auto-renovação, iniciação tumoral, migração e metástases podem ser
responsáveis pela manutenção e renovação deste tumor. No entanto, ainda não
existe um consenso sobre a verdadeira participação das mesmas, porque a sua
identificação e caracterização é ainda um desafio experimental. Objetivo: Este
trabalho busca identificar células com expressão de marcadores de células
tumorais progenitoras em amostras de câncer escamocelular de cavidade oral e
relacioná-las com os estádios de diferenciação do tumor. Metodologia: nesta
investigação, foram escolhidas 32 amostras de pacientes com carcinoma
escamocelular da cavidade oral. Foram detectados no local, através da técnica
de imunofluorescência, quatro marcadores reconhecidos de células tumorais
progenitoras. Resultados: foram identificados os marcadores OCT 4, SSEA 4,
NANOG e TRA-1-60 nos diferentes estádios de diferenciação tumoral, o que
sugere a participação das células progenitoras tumorais na evolução desta
patologia. Conclusões: o estabelecimento e correta identificação das células
tumorais progenitoras abre novas vias terapêuticas para a abordagem deste
tumor, em busca de melhorar o prognóstico, taxa de sobrevivência e qualidade
de vida do paciente.
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Copyright (c) 2022 Marisol Campuzano-Castellanos, Manuel García-Flórez