Revisión sistemática: estrategias virales para la inducción de cáncer “virus de Epstein-Barr: latencia y mecanismos asociados a la oncogénesis viral”
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Palavras-chave

Virus de Epstein Barr
oncogenes
proteínas virales
latencia
expresión génica
herpesvirus

Como Citar

Plata, L., Oviedo, J., & Rincón Orozco, B. (2018). Revisión sistemática: estrategias virales para la inducción de cáncer “virus de Epstein-Barr: latencia y mecanismos asociados a la oncogénesis viral”. Salud UIS, 50(3), 257–268. https://doi.org/10.18273/revsal.v50n3-2018010

Resumo

La infección crónica con virus oncogénicos es responsable de aproximadamente el 20% de todos los cánceres reportados en humanos, este proceso de oncogénesis viral presenta una naturaleza compleja, multietapa y multifactorial. Un ejemplo de ello es el Virus de Epstein- Barr (EBV), un herpesvirus que infecta de manera latente a más del 90% de la población. Aunque la infección a menudo cursa de manera asintomática, el EBV es capaz de modificar su expresión genómica estableciendo diferentes fases de latencia, alterando así el metabolismo de sus células blanco, como son los linfocitos B y las células epiteliales, proceso que resulta determinante en la aparición y desarrollo de diferentes patologías que van desde la mononucleosis infecciosa hasta procesos oncológicos como el linfoma de Burkitt, el cáncer gástrico o el cáncer nasofaríngeo. 

https://doi.org/10.18273/revsal.v50n3-2018010
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